Success story: Eadgene - FOOD-CT-2006-506416
European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety
(from 1 September 2004 to 28 Feb 2010)
Genomic tools that elucidate host-pathogen interactions offer new opportunities to devise sustainable solutions to existing and arising problems, through novel diagnostics, intervention, breeding and husbandry strategies. However, relevant genomics research is fragmented and the restructuring of the European research capacity is required to create the scale and breadth of competencies needed to realise these opportunities.
The Network of Excellence “European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety” (EADGENE -over 100 researchers, 13 partners, 10 countries) in the genomics of host-pathogen interactions in animals was set up to bring together sufficient excellence and resources to make a real difference to animal and human health, and improve the quality of animal products.
"Six years ago,
many were sceptical about NoE: What
was the meaning of integration?
Could you really carry out research in a NoE?
Fortunately, some of us were enthusiastic
enough about this idea to get it started.
Gradually, ongoing collaborations have
been strengthened, new collaborations
have been facilitated, exchanges of
people and resources have been taking
place, people have got to know each
other and we have had the pleasure
of meeting at our workshops, partner
meetings, yearly EADGENE days… and a real Network arose!
The “Success Stories” presented in this brochure [pdf] provide true evidence of
the significant outputs and impacts
of the EADGENE NoE; which would not
have happened otherwise… and many
additional successes we didn’t even
think about when we started!
You may be amazed by the diversity
and the quality of achievements. You
will read about integrating resources,
developing and sharing up-to-date
technologies and tools, successful
collaborative research outputs on
host-pathogen interactions in several
models, bridging the gaps between
research and industry, increasing
exchanges of ideas and knowledge
through mobility, workshops and
meetings, while challenging ourselves
with ethical concerns.
will continue as a “European Research
Group”, an informal grouping of our
institutions, and fortunately with the
EADGENE_S project (2-year ECCSA
Activities will also
continue through joined projects in
which many of our partners participate,
e.g. the NADIR (Network for animal
diseases/infectiology research infrastructures
initiative with 15 partners
from within and outside EADGENE
|One of the primary objectives of the EADGENE Network is to coordinate and
facilitate access and sharing of biological resources and advanced technological
facilities through a “virtual laboratory”. To this extent the partners
have established databases of available resources and facilities, a model
Material Transfer Agreement to regulate Intellectual Property issues, and a
list of elements to consider for contracts between a visitor and a hosting
facility. It was also important to agree on common sets of rules regarding
experimental procedures such as Good Laboratory Practices (GLP), Standard Operating Procedures (SOP) and Quality Assurance/ Quality Control (QA/QC).
|Ingrid Olsaker, Norwegian School of Veterinary Science, Norway
|Genome sequences, cDNA resources, and micro-array expression studies
all involve the generation of thousands if not millions of data points.
It is essential that these data are handled correctly and made available
to the wider scientific community in a user-friendly format, conducive to
furthering the understanding of the biological systems being investigated.
Therefore, up-to-date bioinformatics tools are critical in all studies
including genomic data types.
One of the major contributions from EADGENE’s bioinformatics group has been
the production of up-to-date annotation files, allowing the extraction of biological
knowledge from the microarray experiment results (see ‘Virtual Lab’).
|Christophe Klopp, INRA, France
|The EADGENE Analytical Tools Group shares expertise from throughout the
Network to provide practical solutions and guidance for analysis of animal
disease genomics data. The work of this group is very much demand-led,
based on an initial survey, with new topics added as the technologies and
the analysis methods have evolved: a training course for the design and
statistical analysis of micro-array experiments, that is being given regularly,
a workshop on the analysis of micro-array data, a joint EADGENE-SABRE
working group on post-analyses of micro-array data, and a workshop on
bioinformatics and data handling methods.
The successes of this group can
be attributed to the willing cooperation and active participation of the various
researchers from our EADGENE partner institutes, and the willingness of
research groups to share their data and results. In particular,
the publication of 19 scientific papers provides a concrete and
long-lasting output from this group and is a good example
of the collaborative work that can take place within a
Network of Excellence.
|Dirk-Jan de Koning, The Roslin Institute and R(D)SVS, University of Edinburgh, UK
Institute National de la Recherche Agronomique (INRA), France
Wageningen Unversity (WUR), The Netherlands
Animal Science Group Lelystad (ASG-Lelystad), The Netherlands
Institute for Animal Health (IAH), UK
Roslin Institute and R(D)SVS, University of Edinburgh (UEDIN), UK
University of Aarhus Faculty of Agricultural Sciences (formerly DIAS), Denmark
Liege University, Belgium
Ljubljana University, Slovenia
Cordoba University, Spain
Norwegian School of Veterinary Science (NSVS), Norway
Leibniz Institute for Farm Animal Biology (FBN), Germany
Parco Tecnologico Padano (PTP), Italy
European Forum of Farm Animal Breeders (EFFAB)
University of Copenhagen (CeBRA), Denmark
Institute for Pig Genetics (IPG), The Netherlands
EADGENE - FOOD-CT-2004-506416:
European Commission scientific officer:
Jean Charles Cavitte:
Project coordinator: Marie-Hélène Pinard-van der Laan
Address: UMR Génétique Animale et Biologie, Intégrative - bât 211, Equipe Génétique, Immunité, Santé, INRA - Dépt. de Génétique Animale; F-78352 Jouy-en Josas Cedex, France
Brochure: Download [pdf file]