Small molecule with a potentially big impact on Alzheimer's

Thursday, 18 February, 2016
Despite decades of research, a cure for Alzheimer's remains elusive. But work conducted in Europe suggests that the onset and progression of the disease could be prevented or slowed down by a molecule that mimics the activity of a critical protein (neurotrophin) affecting neurons in the brain.

Alzheimer’s current affects around 30 million people worldwide, and the figure is expected to rise as the population ages. The research, conducted in the EU-funded StressAmyloidCascade project, has demonstrated that drugs administered through the blood stream before the onset of Alzheimer-like symptoms in mice, can prevent age-associated cognitive impairments. The same treatment, based on a small-molecule synthetic compound called 7,8-DHF, also shows promise in slowing or even reversing cognitive decline after Alzheimer’s symptoms start to appear.

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Stress cascades and Alzheimer's disease
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