Horizon 2020
The EU Framework Programme for Research and Innovation

Improving the outcome in treatment-resistant schizophrenia

The faster schizophrenia patients receive effective treatment, the better their prognosis. EU-funded researchers are establishing a profile of individuals unlikely to respond to the drugs used in first-line treatment, for whom the last-resort antipsychotic clozapine should be considered sooner. They are also improving the safety of this drug.

The Crestar project looked for genetic and clinical biomarkers that indicate whether a person suffering from schizophrenia is likely to respond to standard antipsychotic drugs or whether clozapine is likely to be required. Coordinated by King’s College London, it draws on thousands of DNA samples donated by patients and healthy individuals across Europe.

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