ICT BIO 2008 :: Satellite event: Transatlantic Workshop on Multi-scale Cancer Modeling

1st Transatlantic Workshop on Multi-scale Cancer Modeling

This workshop will take place alongside the ICT BIO 2008 conference.

NEW: The report of the workshop is now available

Computational and mathematical cancer modeling is already a driving force behind interdisciplinary cancer systems biology. Understanding cancer as a complex dynamic biosystem requires finding ways to investigate and ultimately target its many constituents and their dynamic relationships across multiple scales in space and time – i.e., multi-scale modeling and simulation. Geared towards translation into clinical practice, long term goals of these modeling approaches include supporting patient specific treatment optimization.

Geared towards translation into clinical practice, long term goals of these modelling approaches include supporting patient specific treatment optimization

In recognizing the significant contribution of teams on both sides of the Atlantic to this emergent field of in silico oncology, the US National Cancer Institute and the European Commission jointly support a workshop that is being co-organized by NCI’s Center for the Development of a Virtual Tumor, CViT, and EU’s Advancing Clinico Genomics Trials Program, ACGT.

This workshop aims to present cutting edge approaches, to demonstrate the field’s potential and to discuss common challenges it faces in moving forward. The ideal outcome is facilitated interaction between the teams, increased visibility of the achievements beyond the nascent community and formulation of a shared vision that can be advanced into joint funding programs.

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October 23, 2008

Lunch

13:30-14:00

Opening Remarks
Daniel Gallahan, NIH-NCI
Ilias Iakovidis, European Commission
Thomas Deisboeck, Massachusetts General Hospital
Georgios Stamatakos, National Technical University of Athens

Topic: CARCINOGENESIS

14:00-14:30	Complex Events and Emergence in Cancer Systems Sylvia Nagl, Ph.D. Cancer Institute, The Paul O'Gorman Building University College London www.ucl.ac.uk/cancer/research-groups/cancer-systems-science
14:30-15:00	Temporal and Spatial Scales of Premalignant Clones in Cancer E. Georg Luebeck, Ph.D. Associate Member Program in Computational Biology Fred Hutchinson Cancer Research Center http://myprofile.cos.com/gluebeck
15:00-15:30	Multi-scale Modeling of Functional and Disfunctional Intracellular Modules of Oncogenic Relevance Ravi Radhakrishnan, Ph.D. Assistant Professor of Bioengineering Assistant Professor of Biochemistry and Biophysics Department of Bioengineering University of Pennsylvania http://www.seas.upenn.edu/~biophys
15:30-16:00	Genetic Instability in Cancer: Thresholds and Catastrophes Ricard Sole, Ph.D. Research Professor Complex Systems Lab Universitat Pompeu Fabra http://complex.upf.es/~ricard/

Coffee Break

Topic: PREVASCULAR-VASCULAR PROGRESSION

16:30-17:00	Ab Initio Computational Modeling of Tumor Spheroids Roberto Chignola, Ph.D. Assistant Professor of Immunology Dipartimento Scientifico e Tecnologico Universita' di Verona http://profs.sci.univr.it/~chignola/ http://www.ts.infn.it/physics/experiments/vbl/
17:00-17:30	Modelling Somatic Evolution and Aspects of Vascular Tumour Growth Philip Maini, Ph.D. Professor Centre for Mathematical Biology Mathematical Institute Oxford University http://www.maths.ox.ac.uk/~maini/
17:30-18:00	In silico Modeling of Solid Tumour Growth and Vascularization Gabor Szekely, Ph.D. Professor Medical Image Analysis and Visualization Group Computer Vision Laboratory Swiss Federal Institute of Technology ETHZ Zurich http://www.vision.ee.ethz.ch

Topic: INVASION AND METASTASIS

18:00-18:30

Multi-scale Simulation of Tumor Cell Adhesion: At the Interface of Statistical Mechanics and Cell Biology
Muhammad H. Zaman, Ph.D.
Assistant Professor
Department of Biomedical Engineering,
The University of Texas at Austin
http://zlabs.bme.utexas.edu/

Cocktail

October 24, 2008

Topic: INVASION AND METASTASIS (continued)

11:30-12:00	Computational Modeling Identifies Morphologic Predictors of Tumor Invasion Vittorio Cristini, Ph.D., FAAN Associate Professor of Health Information Sciences and Biomedical Engineering The University of Texas Health Science Center, Houston Associate Professor of Systems Biology The University of Texas MD Anderson Cancer Center Associate Professor of Biomedical Engineering The University of Texas, Austin School of Health Information Sciences The University of Texas Health Science Center http://cristinilab.shis.uth.tmc.edu
12:00-12:30	Do Tumour Invasion Strategies Follow Basic Physical Laws? Caterina Guiot, Ph.D. Associate Professor of Medical Physics Department of Neuroscience University of Torino
12:30-13:00	The Evolution of Metastasis Carlo Maley, Ph.D. Assistant Professor Molecular and Cellular Oncogenesis Program Systems Biology Division The Wistar Institute http://www.wistar.org/research_facilities/maley/research.htm

Lunch

13:30-14:00

Mathematical Approaches to Modeling Immune-Cancer Dynamics
Lisette de Pillis, Ph.D.
Norman F. Sprague Professor of Life Sciences and Professor of Mathematics
Department of Mathematics
Harvey Mudd College
http://www.math.hmc.edu/~depillis/

Topic: TUMOUR GROWTH ACROSS SPATIOTEMPORAL SCALES

14:00-14:30	Building Tumor Models Using GGH Modeling and CompuCell3D James A. Glazier, Ph.D. Professor Biocomplexity Institute and Department of Physics Indiana University, Bloomington http://biocomplexity.indiana.edu/jglazier/
14:30-15:00	Multiscale Modelling of Colorectal Cancer and Vascular Tumour Growth Helen Byrne, Ph.D. Professor Centre for Mathematical Medicine and Biology School of Mathematical Sciences University of Nottingham http://www.maths.nottingham.ac.uk/research/cmmb/
15:00-15:30	Multiscale Mathematical Modelling of Vascular Tumour Growth Mark Chaplain, Ph.D. Professor Division of Mathematics University of Dundee http://www.maths.dundee.ac.uk/~chaplain
15:30-16:00	Multi-scale Agent-based Cancer Modeling Thomas S. Deisboeck, M.D. Assistant Professor of Radiology (HMS, MGH, HST) Director, Complex Biosystems Modeling Laboratory, Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital-East http://biosystems.mit.edu/ https://www.cvit.org/

Coffee Break

Topic: CLINICALLY ORIENTED TUMOUR MODELING

16:30-17:00	Clinical Requirements Regarding In Silico Oncology Norbert Graf, M.D. Professor , Director of the Oncology and Haematology Clinic University Clinic of Saarland
17:00-17:30	The Role of the Glycolytic Phenotype in Tumor Biology: From Mathematical Models to Clinical Therapy Robert A. Gatenby, M.D. Director of Cancer Imaging and Integrative Mathematical Oncology Moffitt Cancer Center
17:30-18:00	Predictive Multi-scale Modeling of Glioma Growth and Invasion in Individual Patients Kristin Rae Swanson, Ph.D. Assistant Research Professor of Pathology Adjunct Assistant Research Professor of Applied Mathematics Department of Pathology, University of Washington School of Medicine Laboratory of Neuropathology, Harborview Medical Center http://www.pathology.washington.edu/research/labs/labpage.php?LAB=swanson http://www.amath.washington.edu/~swanson
18:00-18:30	Clinically Oriented Cancer Multilevel Modeling Based on Discrete Event Simulation Georgios Stamatakos, Ph.D. Research Associate Professor Leader, In Silico Oncology Group Laboratory of Microwaves and Fiber Optics Institute of Communication and Computer Systems School of Electrical and Computer Engineering National Technical University of Athens http://www.in-silico-oncology.iccs.ntua.gr/ https://www.cvit.org/teampages?uri0=urn:lsid:telar.cambridgesemantics.com:cvit&uri1=user_gstamatakos

18:30-18:45	Closing Remarks Thomas Deisboeck & Georgios Stamatakos

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Last update by the Editor (INFSO-ICTBIO2008(at)ec.europa.eu): 10/11/08

Co-organisers

NEW: Workshop report

European Commission

CViT

ACGT

National Cancer Institute