Table 13-6: Known prehaptens and prohaptens.

Fragrance substance Activation by air oxidation Bioactivation (oxidation) Bioactivation (hydrolysis)
Cinnamyl alcohol x
Eugenol x
Eugenyl acetate x x
Geranial x x
Geraniol x x
Geranyl acetate x x x
Isoeugenol x
Isoeugenyl acetate x x
Limonene x
Linalool  x
Linalyl acetate x
alpha-Terpinene. x x

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, page 118