Table 11 Major resistance mechanisms (Davin-Regli et al. 2008)
|
Mechanism
|
Mechanical barrier
|
Enzymatic barrier
|
Target protection barrier
|
|
Type of activity
|
Influx
|
Efflux, active expel
|
Cleavage
|
Alteration
|
Target mutation
|
Protective molecule, new molecules
|
|
Susceptible antibiotic
|
ß-lactam, Quinolone etc.
|
ß-lactam, Aminoside etc.
|
ß-lactam
|
Phenicol, aminoside etc.
|
Quinolone, MLS etc.
|
ß-lactams, quinolone
|
Source: SCENIHR,  Assessment of the Antibiotic Resistance Effects of Biocides (2009),
Section 3.5.1Resistance mechanisms to antibiotics, p. 41
|
