Table 5-1: Contact allergic reactions to the autoxidised fragrance substances limonene, linalool,
caryophyllene, myrcene and linalyl acetate in consecutive dermatitis patients.
| INCI name |
CAS no |
Test conc. (%) |
n Positive/n tested (%) |
Comments (Ref.) |
Notes: § Bicentric or multicentre studies.
(ox.) Oxidised. |
| D-Limonene (ox.) |
5989-27-5 |
5 |
18/703 (2.6%) |
§ (130) |
| 2 |
28/1172 (1.6%) |
| 3 |
3/362 (0.83%) |
| D-Limonene (ox.) |
5989-27-5 |
3 |
63/2273 (2.8%) variation between centres: 0.3-6.5% |
§ (131) |
| D-Limonene (ox.) |
5989-27-5,
5989-54-8,138-86-3 |
3 |
49/1812 (2.3%) |
§ (134) |
| L-Limonene (ox.) |
36/1812 (2.0%) |
| D – and/or L- Limonene (ox.) |
63/2411 (2.6%) |
| Linalool (ox.) |
78-70-6 |
2 |
20/1511 (1.3%) variation between centres: 0.4-2.7% |
§ (133) |
| Caryophyllene (ox.) |
88-44-5 |
3.9 |
2/1511 (0.1%) |
| Myrcene (ox.) |
123-35-3 |
3 |
1/1511 (0.1%) |
| Linalool (ox.) |
78-70-6 |
2 |
14/1693 (0.83%) |
§ (135) |
| 4 |
67/2075 (3.2%) |
| 6 |
91/1725 (5.3%) |
| 11 |
72/1004 (7.2%) |
| Linalool (ox.) |
78-70-6 |
3 |
11/483 (2.3%) |
(145) |
| Linalyl acetate (ox.) |
115-95-7 |
6 |
13/1217 (1.1%) |
(141) |
Source:
SCCS,  Opinion on Fragrance allergens in cosmetic products, page 35
|