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Notícias (Envelhecimento)

This section on health in the EU has been created as a trustworthy gateway to a wide range of information and data on health-related issues and activities at both European, national and international level. The content is produced by the European Commission, the Member States of the EU and the European Economic Area (EEA), plus EU candidate countries; by international organisations; and by pan-European non-governmental organisations in the area of public health.

Drugs for Parkinson's disease can turn patients into gamblers, sex addicts and compulsive shoppers

Drugs commonly prescribed to treat Parkinson's disease increase the risk of behaviours such as sex addiction, compulsive shopping and gambling, research has found.[...]

Upregulation of GPR109A in Parkinson's Disease

The findings of associations among the GPR109A receptor, niacin levels and night-sleep function in individuals with PD are novel. Further studies are needed to understand the pathophysiological mecha[...]

Predictors of the psychosocial impact of being a carer of people living with Parkinson's disease: A systematic review

Confident conclusions could not be drawn regarding the most important predictors that should be targeted in psychosocial interventions due to methodological weaknesses and lack of theoretical testing[...]

Active & healthy ageing - Just Published - EU Bookshop

A European innovation partnership[...]

The EPDA's My PD Journey Project starts work on a new Parkinson's disease Composite Quality of Life Scale

Work has begun to develop a new composite scale for motor and non-motor symptoms of Parkinson's disease.[...]

The EPDA's My PD Journey Project starts work on a new Parkinson's disease Composite Quality of Life Scale

Work has begun to develop a new composite scale for motor and non-motor symptoms of Parkinson's disease.[...]

Random Whole Body Vibration over 5 Weeks Leads to Effects Similar to Placebo: A Controlled Study in Parkinson's Disease

Conclusions. Random WBV training over 5 weeks seems to be less effective than reported in previous studies performing short-term training. The slight improvements in the FRT and TUG are not clinicall[...]

Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson's Disease

Although there was no significant difference between PD patients and control individuals regarding chemokines levels, our preliminary results showed that CXCL10/IP-10 may be associated with cognitive[...]

Mind matters: placebo enhances reward learning in Parkinson's disease

Authors found that the mere expectation of dopamine release enhanced reward learning and modulated learning-related signals in the striatum and the ventromedial prefrontal cortex. These effects were [...]

Autonomic Dysfunction in Parkinson's Disease With and Without Deep Brain Stimulation

New findings from The Parkinson Alliance (PA) survey entitled Autonomic Dysfunction in Parkinson's Disease With and Without Deep Brain Stimulation show that autonomic dysfunction was highly prevalent[...]

Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study

This study demonstrates that neurocognitive deficits are common even in recently diagnosed patients with Parkinson's disease, and that the associated regional brain activations are influenced by geno[...]

Transdermal rotigotine in advanced Parkinson's disease: a randomized, double-blind, placebo-controlled trial

There was a significantly greater reduction in the off-time (p = 0.014) in the rotigotine group. Rotigotine was well tolerated, with serious adverse events being reported in only three patients in ea[...]

New treatments for the motor symptoms of Parkinson's disease

Authors provide an update since 2011 on new formulations of current drugs, new drugs with promising results in Phase II and Phase III clinical trials, old drugs with new possibilities and some new po[...]

Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease

Together, these findings indicate that expansions in C9orf72 do not have a major role in the pathogenesis of PD. Testing for C9orf72 repeat expansions should only be considered in patients with PD wh[...]

Predictors of dementia in Parkinson disease

Conclusion: Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.[...]

A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine

Study results document for the first time a disturbance of ERK1/2 signaling regulation associated with apomorphine-induced involuntary movements in a genetic mouse model of synucleinopathy. This mous[...]

Parkinson disease and smoking revisited

Authors propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent neuroprotective eff[...]

Dopaminergic agents and nutritional status in Parkinson's disease

Results: In linear regression, total levodopa (l-dopa) equivalent daily dose (LEDD) was associated with worse MNA (B = 0.14, 95% CI = 0.26-0.02; P = 0.019). This association remained significant only[...]

Parkinson's UK appoints Research Director to ignite industry collaboration

Parkinson's UK has appointed leading pharma industry expert Dr Arthur Roach as their Research Director in a bid to spearhead collaboration between Parkinson's medical research and industry.[...]

Peripheral nervous system involvement in Parkinson's disease: evidence and controversies

In this review, authors discuss the different hypotheses, as well as our perspective on open issues and controversies.[...]

Structural MRI correlates of the MMSE and pentagon copying test in Parkinson's disease

Study results suggest MMSE and the pentagon item reflect brain changes which at a regional level involve mainly posterior regions. Correlates of the pentagon item were seen in the same regions where [...]

Catechol-O-methyltransferase Val158Met polymorphism: Modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's

The purpose of this study was to characterize the correlation between the Val158Met polymorphism in the COMT gene and the motor complication wearing-off in Chinese PD patients. Authors have sequenced[...]

Abnormal MoCA and Normal Range MMSE scores in Parkinson disease without dementia: Cognitive and Neurochemical Correlates

Conclusion: PD subjects with normal range MMSE but abnormal MoCA scores had evidence of caudate nucleus dopaminergic denervation and mild cognitive changes, predominantly in executive function. The M[...]

Does a volume reduction of the parietal lobe contribute to freezing of gait in Parkinson's disease?

Study results suggest that a specific pattern of cortical volume reduction involving posterior parietal cortex contributes to the occurrence of FOG in PD. These data agree with the growing body of ev[...]

Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2

In conclusion, significant differences were not detected between R1441G-PD and i-PD in cognitive, depression and anxiety scales, or PD-MCI and PD-Dementia prevalence, and the cognitive profile was id[...]

REM sleep behavior disorder: Association with motor complications and impulse control disorders in Parkinson's disease

Conclusion: Motor complications and ICRB are more frequent in patients with RBD than in patients without RBD. In addition, motor complications are related to RBD even after adjusting for age and dise[...]

Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life

Conclusions: PD-MCI is a significant, independent factor contributing to poorer QoL in patients with newly diagnosed PD. Those classified with greatest impairment (2.0 SD below normal values) have lo[...]

Health-EU Newsletter - Active and Healthy Ageing

The European Innovation Partnership on Active and Healthy Ageing (EIP-AHA) has redefined the way we look at getting old. We are now more aware that the lifestyle choices we make today will greatly i[...]

Sensitive measures of executive dysfunction in non-demented Parkinson's diseas

No significant differences between groups were observed on widely used clinical measures. The PD patients scored lower than controls on the EXAMINER Executive Composite, Cognitive Control, and Workin[...]

Safinamide for the treatment of Parkinson's disease

In this work authors examine the biochemical properties of synthetic and natural molecules that are capable of interfering on both DA system (via monoamine oxidase inhibition) and AS fibrillation.[...]

The Michael J. Fox Foundation and Intel join forces to improve Parkinson's disease monitoring and treatment through advanced tec

The Michael J. Fox Foundation for Parkinson's Research (MJFF) and Intel Corporation announced today a collaboration aimed at improving research and treatment for Parkinson's disease - a neurodegenera[...]

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

In conclusion, authors here provide the first experimental evidence that different α-synuclein forms can propagate from the gut to the brain, and that microtubule-associated transport is involved in [...]

Dyskinesias and motor symptoms onset in Parkinson disease

Conclusions: The partial association between the body site of motor symptoms and of LID onset likely reflects pathophysiological mechanisms underlying LID.[...]

Rotigotine vs ropinirole in advanced stage Parkinson's disease: A double-blind study

Conclusions: Rotigotine was well tolerated at doses up to 16 mg/24 h and showed similar efficacy to ropinirole except that the application site reaction was much higher in the rotigotine group.[...]

Lundbeck receives grant from The Michael J. Fox Foundation for biological markers identification in Parkinson's disease

A Lundbeck research program aiming to increase the knowledge of how a specific change in a gene (Lrrk2) contributes to an increased risk of developing Parkinson's disease was granted DKK 3,5m from Th[...]

MRI brain scans detect people with early Parkinson's

Oxford University researchers have developed a simple and quick MRI technique that offers promise for early diagnosis of Parkinson's disease[...]

NIH scientists find six new genetic risk factors for Parkinson's

Using data from over 18,000 patients, scientists have identified more than two dozen genetic risk factors involved in Parkinson's disease, including six that had not been previously reported. The stu[...]

International Parkinson's Empowerment Summit 2014

The Davis Phinney Foundation and Move4Parkinson's invite people living with Parkinson's, their families and care partners to join them for a unique, international event in Dublin, Ireland.[...]

First clinical data of therapeutic Parkinson's disease vaccine encourages continued development

AFFiRiS AG announced today at a press conference in New York results of AFF008, a Phase I clinical trial of PD01A, a vaccine against Parkinson´s disease. PD01A is the first therapy against the protei[...]

Distinguishing between Progressive Supranuclear palsy and Parkinson's disease

Progressive Supranuclear palsy (PSP) and Parkinson's Disease (PD) have overlapping symptoms but remain difficult to distinguish.[...]

Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study

Conclusion: Subjects with DAT deficit who do not meet criteria for a diagnosis of PD can be identified by olfactory testing. Sequential biomarker assessment may identify those at risk of PD.[...]

Frontal deficits differentiate progressive supranuclear palsy from Parkinson's disease

These findings suggest that more severe and prominent 'frontal' cognitive deficits in patients with progressive parkinsonism would be helpful in predicting progressive supranuclear palsy rather than [...]

7 tesla magnetic resonance imaging: A closer look at substantia nigra anatomy in Parkinson's disease

This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organizatio[...]

Parkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity

Though the results are not always consistent, nevertheless, this body of evidence supports the role of the STN in inhibitory and executive control.[...]

Norepinephrine Deficiency in Parkinson's Disease: The Case for Noradrenergic Enhancement

In addition to reducing the consequences of deficient noradrenergic signaling, enhancement strate gies have the potential for augmenting the effects of dopaminergic therapies in PD. Furthermore, earl[...]

Controversial fetal cell transplants revived for Parkinson's trials

For the last 25 years, using fetal tissue for scientific research has largely fallen out of favor in both the European and U.S. scientific communities. One of the most publicised uses of the controve[...]

Swallowing disturbances in Parkinson's disease: A multivariate analysis of contributing factors

Conclusions: Gender, age, disease duration and dementia all seem to contribute to the occurrence of swallowing disturbances independently. However, the role played by these factors in sub-groups of p[...]

Brains in the balance: New $11.5M grant fuels University of Michigan Parkinson's disease research center to aid patients

NIH grant creates Udall Center of Excellence for Parkinson's Disease Research focused on developing a treatment to prevent falls.[...]

Herbs treating Parkinson's disease

This article reviews herbs that have been documented to have a neuroprotective effect in vitro and in vivo Parkinson's disease (PD) model systems. Authors summarized the anti-Parkinsonian activities [...]

The dopaminergic system in upper limb motor blocks (ULMB) investigated during bimanual coordination in Parkinson's disease (PD)

The current study investigated the occurrence of ULMB in PD participants without ('off') and with ('on') dopamine replacement using bimanual wrist flexionextension with external auditory cues.[...]

Parkinson's disease and age: The obvious but largely unexplored link

The risk of Parkinson's disease increases dramatically in individuals over the age of 60 and it is estimated that more than 1% of all seniors have some form of the condition. In this review, authors [...]

Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease

Study results demonstrate that exercise training was effective for neuroprotection in the striatum and the hippocampus in an experimental model of PD.[...]

Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation

Conclusions: Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.[...]

Parkinson's disease beyond 20 years

Objective: To characterise PD 20 years after onset, investigating the impact of age at onset and disease duration on the clinical picture and the predictors of outcomes in patients reaching the 20-ye[...]

Cognitive executive impairment and dopaminergic deficits in de novo Parkinson's disease

Study findings support the hypothesis that nigrostriatal dopaminergic deficit is associated with executive impairment, but not to memory or visuospatial impairment, in early PD.[...]

The American Parkinson Disease Association Awards $1.1 million in Research Grants and Continues to Lead the Way to Ease the Burd

The American Parkinson Disease Association is pleased to award research funding supporting seven Research grants to junior investigators pursuing research in Parkinson's disease, three Post-Doctoral [...]

Comparison of sleep and other non-motor symptoms between SWEDDs patients and de novo Parkinson´s disease patients

Conclusions: The patients with SWEDDs have less non-motor problems than newly diagnosed untreated PD patients. Given the difficulty distinguishing between SWEDDs and early PD, identifying some of non[...]

Alpha-synuclein repeat variants and survival in Parkinson's disease

In this large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.[...]

Magnetic resonance support vector machine discriminates essential tremor with rest tremor from tremor-dominant Parkinson disease

Results: SVM classification of individual patients showed that no single predictor was able to fully discriminate patients with tPD from those with rET. By contrast, when all predictors were combined[...]

Peptidoglycan recognition protein genes and risk of Parkinson's disease

Authors tested the hypothesis that variants in genes that encode PGRPs are associated with PD risk. Participants in two independent case-control studies were genotyped for 30 single-nucleotide polymo[...]

Development and validation of a new screening questionnaire for dysphagia in early stages of Parkinson's disease

The two-phased project comprised the questionnaire, diagnostic scales construction (N=105), and a validation study (N=82). Data for the project were gathered from PD patients at a German Movement Dis[...]

Suprathreshold odor intensity perception in early-stage Parkinson's disease

Conclusions: Parkinson's disease (PD) influences suprathreshold estimates of perceived odor intensity, negating the notion that such perception might be spared in this disease. No association with do[...]

Reduced thalamic volume in Parkinson Disease with REM Sleep Behavior Disorder: volumetric study

Study findings suggest that the presence of RBD symptoms in PD patients is associated with a reduced thalamic volume suggesting a pathophysiologic role of the thalamus in the complex circuit causing [...]

High-frequency oscillations in Parkinson's disease: Spatial distribution and clinical relevance

Authors found a focal spatial distribution of high-frequency oscillations with highest power 2 mm below the dorsolateral border of the subthalamic nucleus. Within the subthalamic nucleus, power peake[...]

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

In conclusion, study findings cast doubt on the pathogenic role of α-synuclein aggregates in elderly, but do suggest that the severity of neurodegeneration and local burden of α-synuclein pathologica[...]

Association of COMT and MAO-B Gene Polymorphisms with motor complications in Parkinson's Disease in a Chinese population

Study findings suggest that polymorphisms in COMT and MAO-B may increase the risk of wearing-off and dyskinesias. COMT (GG) genotype may be the risk factor of wearing-off. While MAO-B (AG) genotype m[...]

Two-year, randomized, controlled study of safinamide as add-on to levodopa in mid to late Parkinson's disease

This 2-year, controlled study of add-on safinamide in mid-to-late Parkinson's disease with motor fluctuations, although not demonstrating an overall difference in dyskinesias between patients and con[...]

Relation Between Freezing of Gait and Frontal Function in Parkinson's Disease

This is the first study to assess the relation between FOG in the 'on' state and frontal dysfunction evaluated using Behavioral Assessment of the Dysexecutive Syndrome (BADS),[...]

Natural history of falls in a population-based cohort of patients with Parkinson's disease: an 8-year prospective study

Nearly of the PD cohort reported falling after 8 years of follow-up. Disease-specific gait and axial impairments were the major risk factors for future falls in non-fallers at baseline. This has impl[...]

New pan-European pension fund to boost researcher mobility

European Commission Press release Brussels, 1 October 2014 Mobility of researchers in Europe received a boost today with the launch of a consortium that aims to establish a new pan-European pension a[...]

Chromosome 22q11.2 deletion may contain a locus for recessive early-onset Parkinson's disease

Herein, authors propose a hypothesis that it is not the microdeletion per se that is responsible for the phenotype but rather a complete loss of function of a gene within the region due to the combin[...]

Cognitive and cortical thinning patterns of subjective cognitive decline in patients with and without Parkinson's disease

Study data show that cortical thinning and cognitive performance in patients with SCD may differ based on the presence of PD, suggesting that SCD in patients with PD reflects disease-related cortical[...]

Predictors of dementia in Parkinson's disease; findings from a 5-year prospective study using the SCOPA-COG

These findings largely corresponded with the variables that were associated with the presence of dementia at baseline. In a stepwise regression model, higher age at baseline, fewer years of education[...]

The Impact of STN Deep Brain Stimulation on Speech in Individuals with Parkinson's Disease: The Patient's Perspective

Conclusion: DBS therapy's contribution to speech disturbance is gaining more attention, and the speech symptoms ensuing from and/or being exacerbated by DBS are in the incipient stages of being inves[...]

Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population

Authors confirm the association between p.R1628P and risk of developing PD in the appropriated sample-sized cohort. Certain LRRK2 variants appear to be generally distributed among East Asians, howeve[...]

Freezing of Gait subtypes have different cognitive correlates in Parkinson's disease

Conclusion: Aside from pharmacological differences, unresponsive FOG is associated with executive and visuospatial dysfunction implicating frontostriatal pathways while responsive FOG is associated w[...]

Motor impairment, depression, dementia: Which forms the impression of disease severity in Parkinson's disease?

Conclusion: The additional burden of dementia and depression was underestimated in the CGIS rating, suggesting that they are possibly relativized against the motor impairment.[...]

Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease

Results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an i[...]

Parkinson's UK and Global Kinetics Corporation collaborate to provide promising new mHealth technology throughout UK

An innovative medical device designed in Australia to improve management of Parkinson's is to be made available in services in the United Kingdom, as part of a 12-month pilot project.[...]

Risk of Parkinson's disease following severe constipation: A nationwide population-based cohort study

The association between constipation at the beginning of the study and the incidence of PD was examined using a Cox regression model. Information regarding comorbidities and concomitant medications u[...]

Course of psychiatric symptoms and global cognition in early Parkinson disease

Conclusion: Multiple NPS are more common in de novo, untreated patients with PD compared with the general population, but they also remain relatively stable in early disease, while global cognition s[...]

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

Study findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities; however, studies with larger samples and specific objectives a[...]

Effects of augmented visual feedback during balance training in Parkinson's disease: A pilot randomized clinical trial

VFT proved to be a feasible and safe approach to balance therapy for patients with PD. In this proof-of-concept study VFT was not superior over conventional balance training although observed trends [...]

Formulations of hormone therapy and risk of Parkinson's disease

The findings from this study suggest an increase in PD risk associated with esterified estrogen use combined with progestin, and no risk associated with conjugated estrogen with progestin. These find[...]

Gait and balance in Parkinson's disease subtypes: objective measures and classification considerations

Clinical assessments of the disturbances seen in patients with the PIGD subtype are not consistent with objective measures; overlapping between the groups is seen in many objective features of gait a[...]

Mendelian randomization of serum urate and Parkinson's disease progression

The study was conducted among participants in DATATOP and PRECEPT, two randomized trials among patients with early PD. The 808 patients with available DNA were genotyped for three SLC2A9 single nucle[...]

Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's Disease

Conclusion: In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of this study do not support the notion that PSG-confirmed RBD and ICD sha[...]

Over 700 people take a step forward for Parkinson's at the European Unity Walk

The 2nd European Unity Walk took part in the beautiful heart of Luxembourg was a huge success marked by unity and public awareness.[...]

Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation

In this retrospective study, authors compared motor disease progression in Ashkenazi-Jewish (AJ) Parkinson's disease (PD) patients carrying the LRRK2*G2019S mutation with that of noncarriers.[...]

Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson's disease

Results demonstrated a significantly greater improvement in total UPDRS scores from baseline to week 18 in the rasagiline group compared with the placebo group (least squares [LS] mean difference  SE[...]

Cerebral microbleeds in patients with Parkinson's disease

The present data demonstrate that even though CMBs were inseparably associated with the presence of WMHs, CMBs occur more commonly in PD patients with dementia than in those without dementia. Additio[...]

Cardiac stress test is normal in pre-motor Parkinson's disease

Authors retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rat[...]

Subjective memory complaints, depressive symptoms and cognition in Parkinson's disease patients

Background and purpose: The goal of this study was to establish the prevalence of subjective memory complaints (SMCs) and depressive symptoms (DS)s and their relation to cognitive functioning in pati[...]

Dopaminergic medication does not improve stepping responses following backward & forward balance perturbations in Parkinson's

In conclusion, dopaminergic medication does not improve underscaling of stepping responses in PD. Therefore, other interventions are needed to improve these important defense postural reactions.[...]

Apathy in untreated, de novo patients with Parkinson's disease: validation study of Apathy Evaluation Scale

The AES-S is a reliable and valid questionnaire for detecting apathy in PD. For screening purposes a 33/34 cut-off score is indicated, but a 38/39 cut-off score is necessary when a high specificity i[...]

Characterizing motor and non-motor aspects of early-morning off periods in Parkinson's: An international multicenter study

Results: The results demonstrate that EMO periods are common and occur in 59.7% of subjects across all disease stages in line with other reports. However, importantly, in 88.0% of those, EMOs were fo[...]

Cost of deep brain stimulation for the treatment of Parkinson's disease by surgical stimulation sites

Provider costs were similar for the 144 GPi and 130 STN patients (GPi: $138,044 vs. STN: $131,822; difference = $6,222, 95% confidence interval [CI]: $42,125 to $45,343). Societal costs were also sim[...]

Does a specialist unit improve outcomes for hospitalized patients with Parkinson's disease?

The general ward care (n=20) and the Specialist Parkinson's Unit care (n=24) groups had similar baseline characteristics. On the specialist unit: less Parkinson's medication was omitted (13% v 20%, p[...]

Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson's disease: A case series

Discussion: Hypersexuality and delusional jealousy may occur independently in PD patients on dopamine agonist therapy, but may develop together probably reflecting a common alteration of sexuality (s[...]

The Cognition & Emotional Well-being indices of the Parkinson's Disease Questionnaire-39: What do they really measure?

Conclusions: The PDQ-39 Cognition index may be more related to mood functioning, as opposed to cognitive functioning, and should not be considered a proxy for cognitive functioning. Future studies ar[...]

Success Stories - Reducing the risk of Alzheimer's disease and vascular dementia - World Alzheimer Day 21-09-2014

Dementia is a group of degenerative diseases typically affecting the cognitive abilities of the elderly population. According to the World Health Organization, the estimated proportion of the general[...]

Dementia & severity of parkinsonism determines handicap of patients in late-stage Parkinson's: the BarcelonaLisbon cohort

Methods: Handicap, medical conditions, use of healthcare resources and the impact of LS-PD upon caregivers were characterized in a cross-sectional study of LS-PD stages 4 or 5 of Hoehn and Yahr (H&am[...]

Cholinesterase inhibitors for Parkinson's disease: a systematic review and meta-analysis

Conclusions ChIs are effective in the treatment of cognitive impairment in patients with PD, but do not affect risk of falls. The choice of treatment has to be balanced considering the increased trem[...]

Back to the basics: regular exercise matters in Parkinson's: Results from the National Parkinson Foundation registry study

Regular exercisers at baseline was associated with better QOL, mobility, and physical function, less progression of disease, less caregiver burden and less cognitive decline one year later, after con[...]

Dual-task interference and brain structural connectivity in people with Parkinson's disease who freeze

These results support the hypothesis that freezing is related to altered attentional control during gait, and suggest that differences in pedunculopontine nucleus connectivity contribute to poorer at[...]

Effects of cognitive training in Parkinson's Disease: a randomized controlled trial

Cognitive and affective functions can be improved by cognitive trainings in PD patients. Specific effects (e.g. on memory and working memory versus depression) seem to be dependent on the type of tra[...]

Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease

Conclusions: Hippocampal volume is a major factor predicting the development of mild cognitive impairment and dementia in PD. White matter hyperintensity also contributes to the longitudinal cognitiv[...]

Interventions for fatigue in Parkinson's disease: A systematic review and meta-analysis

Currently insufficient evidence exists to support the treatment of fatigue in PD with any drug or nondrug treatment. Further study is required.[...]

Lower plasma Apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype

results are compatible with a model whereby circulating ApoA1 levels may be useful in risk-stratifying subjects for the development of PD, with higher ApoA1 levels suggesting relative protection. Fut[...]

Midlife migraine and late-life parkinsonism

These findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are need[...]

Puerarin protects dopaminergic neurons in Parkinson's disease models

These data indicated that puerarin alleviated the oxidative stress and apoptosis in a PD cellular model, protected the dopaminergic neurons against rotenone toxicity and decreased the abnormal protei[...]

EPDA Move for Change survey shows Parkinson's care standards are lagging just one in 10 patients are diagnosed by a disease ex

Care provision in Parkinson's disease is falling dismally short of the standards patients and carers have every right to expect, research across Europe indicates.[...]

The role of iron in brain ageing and neurodegenerative disorders

During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's [...]

Researchers debunk myth about Parkinson's disease

BRAIN RESEARCH - Using advanced computer models, neuroscience researchers at the University of Copenhagen have gained new knowledge about the complex processes that cause Parkinson's disease. The fin[...]

Pooled analysis of phase III with entacapone in Parkinson's disease

Conclusions: Entacapone improved daily OFF- and ON-times by a mean of 0.8 h compared with placebo across the four pooled efficacy studies and was generally well tolerated. The results of this pooled [...]

Prevalence of Malnutrition in Patients with Parkinson's: Comparative Study with Healthy Controls using MNA questionnaire

Study findings indicate the same nutritional status among mild to moderate PD patients compared with healthy controls. However, more than a quarter of the PD population was found to be at risk of mal[...]

Parkinson disease and smoking revisited

Authors propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent neuroprotective eff[...]

Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease

This is the first study indicating that the SLC6A3/DAT1 genotype has a significant effect on fronto-striatal activation and performance in Parkinson's disease. This effect is stronger for conditions [...]

Dance for people with Parkinson's disease: what is the evidence telling us?

Conclusions: Dance may be helpful for some people with PD. This paper provides preliminary information to aid clinicians when implementing dance programmes for people with PD. Higher quality multi-ce[...]

Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease

Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with hea[...]

Survey reveals knowledge gaps among Parkinson's patients and caregivers

A recent survey of more than 1,500 Parkinson's disease (PD) patients, caregivers and physicians reveals that information and specialized care can help patients become more engaged in their own treatm[...]

Differentiating drug-induced parkinsonism from Parkinson's disease: An update on non-motor symptoms and investigations

Authors performed a review to ascertain whether assessment of non-motor symptoms, or use of ancillary investigations, namely dopamine transporter imaging, transcranial sonography of the substantia ni[...]

Mortality in Parkinson's disease is not associated with the severity of early dopaminergic defect

Results: Mortality rate was 56.8%. Although higher age (p 0.48).[...]

Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries

Objective: To assess QoL and its association with on-off fluctuations, peak-dose dyskinesias, biphasic dyskinesias, and off-dystonias in PD patients from five European countries.[...]

The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa

Authors conclude that motor fluctuations and dyskinesias are not associated with the duration of levodopa therapy, but rather with longer disease duration and higher levodopa daily dose. Hence, the p[...]

Canadian Study of Neurological Conditions Provides New Vital Information on the Impact of Parkinson's Disease

Parkinson Society Canada is excited to share today's release of the report on The National Population Health Study of Neurological Conditions by the Public Health Agency of Canada in partnership with[...]

Short rapid steps to provoke freezing of gait in Parkinson's disease

The combination of 'full rapid turns' and 'walking with short steps rapidly' yielded the highest sensitivity of provoking FOG (0.71, CI 0.510.86). The most sensitive way to provoke FOG is by asking p[...]

Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease

Conclusions: STN-DBS decreased pain after surgery, but had different effects in different types of PD-related pain. Motor and nonmotor symptom improvements after STN-DBS did not correlate with pain r[...]

Dopaminergic agents and nutritional status in Parkinson's disease

Results: In linear regression, total levodopa (l-dopa) equivalent daily dose (LEDD) was associated with worse MNA (B = 0.14, 95% CI = 0.26-0.02; P = 0.019). This association remained significant only[...]

Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility

Although limited in this group of patients, speech impairment following pedunculopontine nucleus area stimulation is a possible outcome that should be considered before undertaking such surgery. Dele[...]

2012 European Year for Active Ageing and Solidarity between generations (EY2012) – Evaluation report

The European Commission has adopted a report today on the implementation, results and overall assessment of the 2012 European Year for Active Ageing and Solidarity between Generations.[...]

Device to help people with Parkinson's disease communicate better now available

SpeechVive Inc. announced Wednesday (Sept. 10) the commercial launch of the SpeechVive device intended to help people with a soft voice due to Parkinson's disease speak more loudly and communicate mo[...]

Cortical volume and folding abnormalities in Parkinson's disease patients with pathological gambling

This study demonstrates that combined grey matter atrophy and reduced lGI in the OFC differentiates PD patients with PG from those without PG, suggesting that this cortical area may play a critical r[...]

Glucocerebrosidase mutations in primary parkinsonism

Conclusion: GBA dysfunction is relevant for synucleinopathies, such as PD and DLB, except for MSA, in which pathology involves oligodendrocytes, and the tauopathies PSP and CBD. The risk of developin[...]

Parkinson's Disease Foundation Announces Newest Series of Community-Driven Online Seminars

The Parkinson's Disease Foundation (PDF) is pleased to announce its sixth series of PD ExpertBriefings, free interactive seminars presented by leaders in Parkinson's disease research and care.[...]

'Pocket doctor' phone app could measure Parkinson's progression

Parkinson's disease and other degenerative motor system disorders are notoriously difficult to diagnose accurately. But now, new research has resulted in a new application that enables smartphones to[...]

Summary of Optimum Continence Service Specification

In this summary document authors have included the results of a model constructed to assess the expected clinical, quality of life and economic impact of this service specification on people with inc[...]

Later age at onset in Parkinson's disease over twenty years in an Italian tertiary clinic

Conclusions: Over the last two decades, age at onset of PD appeared to shift progressively towards more advanced age. However, sequential, high quality population-based incidence studies are required[...]

Stepping out for people with Parkinson's

With only a couple of weeks to go until the second European Unity Walk, we are all limbering up for what promises to be a hugely enjoyable and inspirational event.[...]

Active and healthy ageing: the importance of nutrition to add healthy life years

The Joint Research Centre (JRC), the European Commission's in-house science service, has published a science and policy report highlighting the importance of diet and nutrition in increasing healthy [...]

KineMed Receives U.S. Patent Allowance for Noscapine to Treat ALS, Parkinson's Disease, and Diabetic Neuropathy

KineMed, Inc. today announced that the company has received a notice of allowance from the U.S. Patent and Trademark Office for the invention entitled: Compositions and Methods of Treatment Using Mod[...]

Move for Change Part III: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's Disease

These results highlight that PD disease-management is driven by the clinician; he/she arranges consultations and makes the majority of management decisions, rather than patients being included in the[...]

Visual short-term memory deficits associated with GBA mutation and Parkinson's disease

These findings provide evidence for dissociable signature deficits within the domain of visual short-term memory associated with GBA mutation and with Parkinson's disease. Identification of the speci[...]

New resource for educators: Experimental protocol: Join in the research to find a drug for Alzheimer's

Home › Experimental protocol: Join in the research to find a drug for Alzheimer's Experimental protocol: Join in the research to find a drug for Alzheimer's Alzheimer's is a neurodegenerative diseas[...]

Call for tender - Normal and pathological aging : mechanisms and consequences on population health    University of Lorraine

The goal is to better understand, prevent and treat the increasingly high number of illnesses due to the pathological aging of cells, tissues and organs. In partnership with the University Hospital o[...]

Success Stories - DECIDE: enabling earlier diagnosis of dementia

DECIDE stands for 'Diagnostic Enhancement of Confidence by an International Distributed Environment'. This FP7 project brought together 13 partners from five European countries, with the Italian GARR[...]

Consumer survey of UK kitchens reveals poor food safety perceptions and behaviour in older people

Research conducted by the University of Hertfordshire, UK, and commissioned by the UK Food Standards Agency (FSA), investigated what happens in household kitchens to assess food safety risks in domes[...]


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