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This section on health in the EU has been created as a trustworthy gateway to a wide range of information and data on health-related issues and activities at both European, national and international level. The content is produced by the European Commission, the Member States of the EU and the European Economic Area (EEA), plus EU candidate countries; by international organisations; and by pan-European non-governmental organisations in the area of public health.

Chromosome 22q11.2 deletion may contain a locus for recessive early-onset Parkinson's disease    epda.eu.com

Herein, authors propose a hypothesis that it is not the microdeletion per se that is responsible for the phenotype but rather a complete loss of function of a gene within the region due to the combin[...]

Predictors of dementia in Parkinson's disease; findings from a 5-year prospective study using the SCOPA-COG    epda.eu.com

These findings largely corresponded with the variables that were associated with the presence of dementia at baseline. In a stepwise regression model, higher age at baseline, fewer years of education[...]

Cognitive and cortical thinning patterns of subjective cognitive decline in patients with and without Parkinson's disease    epda.eu.com

Study data show that cortical thinning and cognitive performance in patients with SCD may differ based on the presence of PD, suggesting that SCD in patients with PD reflects disease-related cortical[...]

The Impact of STN Deep Brain Stimulation on Speech in Individuals with Parkinson's Disease: The Patient's Perspective    epda.eu.com

Conclusion: DBS therapy's contribution to speech disturbance is gaining more attention, and the speech symptoms ensuing from and/or being exacerbated by DBS are in the incipient stages of being inves[...]

Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population    epda.eu.com

Authors confirm the association between p.R1628P and risk of developing PD in the appropriated sample-sized cohort. Certain LRRK2 variants appear to be generally distributed among East Asians, howeve[...]

Freezing of Gait subtypes have different cognitive correlates in Parkinson's disease    epda.eu.com

Conclusion: Aside from pharmacological differences, unresponsive FOG is associated with executive and visuospatial dysfunction implicating frontostriatal pathways while responsive FOG is associated w[...]

Motor impairment, depression, dementia: Which forms the impression of disease severity in Parkinson's disease?    epda.eu.com

Conclusion: The additional burden of dementia and depression was underestimated in the CGIS rating, suggesting that they are possibly relativized against the motor impairment.[...]

Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease    epda.eu.com

Results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an i[...]

Parkinson's UK and Global Kinetics Corporation collaborate to provide promising new mHealth technology throughout UK    epda.eu.com

An innovative medical device designed in Australia to improve management of Parkinson's is to be made available in services in the United Kingdom, as part of a 12-month pilot project.[...]

Risk of Parkinson's disease following severe constipation: A nationwide population-based cohort study    epda.eu.com

The association between constipation at the beginning of the study and the incidence of PD was examined using a Cox regression model. Information regarding comorbidities and concomitant medications u[...]

Course of psychiatric symptoms and global cognition in early Parkinson disease    epda.eu.com

Conclusion: Multiple NPS are more common in de novo, untreated patients with PD compared with the general population, but they also remain relatively stable in early disease, while global cognition s[...]

Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial    epda.eu.com

Study findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities; however, studies with larger samples and specific objectives a[...]

Effects of augmented visual feedback during balance training in Parkinson's disease: A pilot randomized clinical trial    epda.eu.com

VFT proved to be a feasible and safe approach to balance therapy for patients with PD. In this proof-of-concept study VFT was not superior over conventional balance training although observed trends [...]

Gait and balance in Parkinson's disease subtypes: objective measures and classification considerations    epda.eu.com

Clinical assessments of the disturbances seen in patients with the PIGD subtype are not consistent with objective measures; overlapping between the groups is seen in many objective features of gait a[...]

Formulations of hormone therapy and risk of Parkinson's disease    epda.eu.com

The findings from this study suggest an increase in PD risk associated with esterified estrogen use combined with progestin, and no risk associated with conjugated estrogen with progestin. These find[...]

Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's Disease    epda.eu.com

Conclusion: In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of this study do not support the notion that PSG-confirmed RBD and ICD sha[...]

Mendelian randomization of serum urate and Parkinson's disease progression    epda.eu.com

The study was conducted among participants in DATATOP and PRECEPT, two randomized trials among patients with early PD. The 808 patients with available DNA were genotyped for three SLC2A9 single nucle[...]

Over 700 people take a step forward for Parkinson's at the European Unity Walk    epda.eu.com

The 2nd European Unity Walk took part in the beautiful heart of Luxembourg was a huge success marked by unity and public awareness.[...]

Randomized, controlled trial of rasagiline as an add-on to dopamine agonists in Parkinson's disease    epda.eu.com

Results demonstrated a significantly greater improvement in total UPDRS scores from baseline to week 18 in the rasagiline group compared with the placebo group (least squares [LS] mean difference  SE[...]

Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation    epda.eu.com

In this retrospective study, authors compared motor disease progression in Ashkenazi-Jewish (AJ) Parkinson's disease (PD) patients carrying the LRRK2*G2019S mutation with that of noncarriers.[...]

Cerebral microbleeds in patients with Parkinson's disease    epda.eu.com

The present data demonstrate that even though CMBs were inseparably associated with the presence of WMHs, CMBs occur more commonly in PD patients with dementia than in those without dementia. Additio[...]

Cardiac stress test is normal in pre-motor Parkinson's disease    epda.eu.com

Authors retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rat[...]

Subjective memory complaints, depressive symptoms and cognition in Parkinson's disease patients    epda.eu.com

Background and purpose: The goal of this study was to establish the prevalence of subjective memory complaints (SMCs) and depressive symptoms (DS)s and their relation to cognitive functioning in pati[...]

Dopaminergic medication does not improve stepping responses following backward & forward balance perturbations in Parkinson's    epda.eu.com

In conclusion, dopaminergic medication does not improve underscaling of stepping responses in PD. Therefore, other interventions are needed to improve these important defense postural reactions.[...]

Apathy in untreated, de novo patients with Parkinson's disease: validation study of Apathy Evaluation Scale    epda.eu.com

The AES-S is a reliable and valid questionnaire for detecting apathy in PD. For screening purposes a 33/34 cut-off score is indicated, but a 38/39 cut-off score is necessary when a high specificity i[...]

Cost of deep brain stimulation for the treatment of Parkinson's disease by surgical stimulation sites    epda.eu.com

Provider costs were similar for the 144 GPi and 130 STN patients (GPi: $138,044 vs. STN: $131,822; difference = $6,222, 95% confidence interval [CI]: $42,125 to $45,343). Societal costs were also sim[...]

Characterizing motor and non-motor aspects of early-morning off periods in Parkinson's: An international multicenter study    epda.eu.com

Results: The results demonstrate that EMO periods are common and occur in 59.7% of subjects across all disease stages in line with other reports. However, importantly, in 88.0% of those, EMOs were fo[...]

Does a specialist unit improve outcomes for hospitalized patients with Parkinson's disease?    epda.eu.com

The general ward care (n=20) and the Specialist Parkinson's Unit care (n=24) groups had similar baseline characteristics. On the specialist unit: less Parkinson's medication was omitted (13% v 20%, p[...]

Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson's disease: A case series    epda.eu.com

Discussion: Hypersexuality and delusional jealousy may occur independently in PD patients on dopamine agonist therapy, but may develop together probably reflecting a common alteration of sexuality (s[...]

The Cognition & Emotional Well-being indices of the Parkinson's Disease Questionnaire-39: What do they really measure?    epda.eu.com

Conclusions: The PDQ-39 Cognition index may be more related to mood functioning, as opposed to cognitive functioning, and should not be considered a proxy for cognitive functioning. Future studies ar[...]

Success Stories - Reducing the risk of Alzheimer's disease and vascular dementia - World Alzheimer Day 21-09-2014    europa.eu

Dementia is a group of degenerative diseases typically affecting the cognitive abilities of the elderly population. According to the World Health Organization, the estimated proportion of the general[...]

Dementia & severity of parkinsonism determines handicap of patients in late-stage Parkinson's: the BarcelonaLisbon cohort    epda.eu.com

Methods: Handicap, medical conditions, use of healthcare resources and the impact of LS-PD upon caregivers were characterized in a cross-sectional study of LS-PD stages 4 or 5 of Hoehn and Yahr (H&am[...]

Back to the basics: regular exercise matters in Parkinson's: Results from the National Parkinson Foundation registry study    epda.eu.com

Regular exercisers at baseline was associated with better QOL, mobility, and physical function, less progression of disease, less caregiver burden and less cognitive decline one year later, after con[...]

Cholinesterase inhibitors for Parkinson's disease: a systematic review and meta-analysis    epda.eu.com

Conclusions ChIs are effective in the treatment of cognitive impairment in patients with PD, but do not affect risk of falls. The choice of treatment has to be balanced considering the increased trem[...]

Effects of cognitive training in Parkinson's Disease: a randomized controlled trial    epda.eu.com

Cognitive and affective functions can be improved by cognitive trainings in PD patients. Specific effects (e.g. on memory and working memory versus depression) seem to be dependent on the type of tra[...]

Dual-task interference and brain structural connectivity in people with Parkinson's disease who freeze    epda.eu.com

These results support the hypothesis that freezing is related to altered attentional control during gait, and suggest that differences in pedunculopontine nucleus connectivity contribute to poorer at[...]

Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease    epda.eu.com

Conclusions: Hippocampal volume is a major factor predicting the development of mild cognitive impairment and dementia in PD. White matter hyperintensity also contributes to the longitudinal cognitiv[...]

Lower plasma Apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype    epda.eu.com

results are compatible with a model whereby circulating ApoA1 levels may be useful in risk-stratifying subjects for the development of PD, with higher ApoA1 levels suggesting relative protection. Fut[...]

Interventions for fatigue in Parkinson's disease: A systematic review and meta-analysis    epda.eu.com

Currently insufficient evidence exists to support the treatment of fatigue in PD with any drug or nondrug treatment. Further study is required.[...]

Puerarin protects dopaminergic neurons in Parkinson's disease models    epda.eu.com

These data indicated that puerarin alleviated the oxidative stress and apoptosis in a PD cellular model, protected the dopaminergic neurons against rotenone toxicity and decreased the abnormal protei[...]

Midlife migraine and late-life parkinsonism    epda.eu.com

These findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are need[...]

EPDA Move for Change survey shows Parkinson's care standards are lagging just one in 10 patients are diagnosed by a disease ex    epda.eu.com

Care provision in Parkinson's disease is falling dismally short of the standards patients and carers have every right to expect, research across Europe indicates.[...]

The role of iron in brain ageing and neurodegenerative disorders    epda.eu.com

During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's [...]

Researchers debunk myth about Parkinson's disease    epda.eu.com

BRAIN RESEARCH - Using advanced computer models, neuroscience researchers at the University of Copenhagen have gained new knowledge about the complex processes that cause Parkinson's disease. The fin[...]

Prevalence of Malnutrition in Patients with Parkinson's: Comparative Study with Healthy Controls using MNA questionnaire    epda.eu.com

Study findings indicate the same nutritional status among mild to moderate PD patients compared with healthy controls. However, more than a quarter of the PD population was found to be at risk of mal[...]

Pooled analysis of phase III with entacapone in Parkinson's disease    epda.eu.com

Conclusions: Entacapone improved daily OFF- and ON-times by a mean of 0.8 h compared with placebo across the four pooled efficacy studies and was generally well tolerated. The results of this pooled [...]

Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease    epda.eu.com

This is the first study indicating that the SLC6A3/DAT1 genotype has a significant effect on fronto-striatal activation and performance in Parkinson's disease. This effect is stronger for conditions [...]

Parkinson disease and smoking revisited    epda.eu.com

Authors propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent neuroprotective eff[...]

Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease    epda.eu.com

Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with hea[...]

Dance for people with Parkinson's disease: what is the evidence telling us?    epda.eu.com

Conclusions: Dance may be helpful for some people with PD. This paper provides preliminary information to aid clinicians when implementing dance programmes for people with PD. Higher quality multi-ce[...]

Survey reveals knowledge gaps among Parkinson's patients and caregivers    epda.eu.com

A recent survey of more than 1,500 Parkinson's disease (PD) patients, caregivers and physicians reveals that information and specialized care can help patients become more engaged in their own treatm[...]

Differentiating drug-induced parkinsonism from Parkinson's disease: An update on non-motor symptoms and investigations    epda.eu.com

Authors performed a review to ascertain whether assessment of non-motor symptoms, or use of ancillary investigations, namely dopamine transporter imaging, transcranial sonography of the substantia ni[...]

Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries    epda.eu.com

Objective: To assess QoL and its association with on-off fluctuations, peak-dose dyskinesias, biphasic dyskinesias, and off-dystonias in PD patients from five European countries.[...]

Mortality in Parkinson's disease is not associated with the severity of early dopaminergic defect    epda.eu.com

Results: Mortality rate was 56.8%. Although higher age (p 0.48).[...]

The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa    epda.eu.com

Authors conclude that motor fluctuations and dyskinesias are not associated with the duration of levodopa therapy, but rather with longer disease duration and higher levodopa daily dose. Hence, the p[...]

Canadian Study of Neurological Conditions Provides New Vital Information on the Impact of Parkinson's Disease    epda.eu.com

Parkinson Society Canada is excited to share today's release of the report on The National Population Health Study of Neurological Conditions by the Public Health Agency of Canada in partnership with[...]

Short rapid steps to provoke freezing of gait in Parkinson's disease    epda.eu.com

The combination of 'full rapid turns' and 'walking with short steps rapidly' yielded the highest sensitivity of provoking FOG (0.71, CI 0.510.86). The most sensitive way to provoke FOG is by asking p[...]

Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease    epda.eu.com

Conclusions: STN-DBS decreased pain after surgery, but had different effects in different types of PD-related pain. Motor and nonmotor symptom improvements after STN-DBS did not correlate with pain r[...]

Dopaminergic agents and nutritional status in Parkinson's disease    epda.eu.com

Results: In linear regression, total levodopa (l-dopa) equivalent daily dose (LEDD) was associated with worse MNA (B = 0.14, 95% CI = 0.26-0.02; P = 0.019). This association remained significant only[...]

Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility    epda.eu.com

Although limited in this group of patients, speech impairment following pedunculopontine nucleus area stimulation is a possible outcome that should be considered before undertaking such surgery. Dele[...]

2012 European Year for Active Ageing and Solidarity between generations (EY2012) – Evaluation report    europa.eu

The European Commission has adopted a report today on the implementation, results and overall assessment of the 2012 European Year for Active Ageing and Solidarity between Generations.[...]

Device to help people with Parkinson's disease communicate better now available    epda.eu.com

SpeechVive Inc. announced Wednesday (Sept. 10) the commercial launch of the SpeechVive device intended to help people with a soft voice due to Parkinson's disease speak more loudly and communicate mo[...]

Cortical volume and folding abnormalities in Parkinson's disease patients with pathological gambling    epda.eu.com

This study demonstrates that combined grey matter atrophy and reduced lGI in the OFC differentiates PD patients with PG from those without PG, suggesting that this cortical area may play a critical r[...]

Glucocerebrosidase mutations in primary parkinsonism    epda.eu.com

Conclusion: GBA dysfunction is relevant for synucleinopathies, such as PD and DLB, except for MSA, in which pathology involves oligodendrocytes, and the tauopathies PSP and CBD. The risk of developin[...]

'Pocket doctor' phone app could measure Parkinson's progression    epda.eu.com

Parkinson's disease and other degenerative motor system disorders are notoriously difficult to diagnose accurately. But now, new research has resulted in a new application that enables smartphones to[...]

Parkinson's Disease Foundation Announces Newest Series of Community-Driven Online Seminars    epda.eu.com

The Parkinson's Disease Foundation (PDF) is pleased to announce its sixth series of PD ExpertBriefings, free interactive seminars presented by leaders in Parkinson's disease research and care.[...]

Summary of Optimum Continence Service Specification    epda.eu.com

In this summary document authors have included the results of a model constructed to assess the expected clinical, quality of life and economic impact of this service specification on people with inc[...]

Later age at onset in Parkinson's disease over twenty years in an Italian tertiary clinic    epda.eu.com

Conclusions: Over the last two decades, age at onset of PD appeared to shift progressively towards more advanced age. However, sequential, high quality population-based incidence studies are required[...]

Stepping out for people with Parkinson's    epda.eu.com

With only a couple of weeks to go until the second European Unity Walk, we are all limbering up for what promises to be a hugely enjoyable and inspirational event.[...]

Active and healthy ageing: the importance of nutrition to add healthy life years    eufic.org

The Joint Research Centre (JRC), the European Commission's in-house science service, has published a science and policy report highlighting the importance of diet and nutrition in increasing healthy [...]

KineMed Receives U.S. Patent Allowance for Noscapine to Treat ALS, Parkinson's Disease, and Diabetic Neuropathy    epda.eu.com

KineMed, Inc. today announced that the company has received a notice of allowance from the U.S. Patent and Trademark Office for the invention entitled: Compositions and Methods of Treatment Using Mod[...]

Move for Change Part III: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's Disease    epda.eu.com

These results highlight that PD disease-management is driven by the clinician; he/she arranges consultations and makes the majority of management decisions, rather than patients being included in the[...]

Visual short-term memory deficits associated with GBA mutation and Parkinson's disease    epda.eu.com

These findings provide evidence for dissociable signature deficits within the domain of visual short-term memory associated with GBA mutation and with Parkinson's disease. Identification of the speci[...]

New resource for educators: Experimental protocol: Join in the research to find a drug for Alzheimer's    xplorehealth.eu

Home › Experimental protocol: Join in the research to find a drug for Alzheimer's Experimental protocol: Join in the research to find a drug for Alzheimer's Alzheimer's is a neurodegenerative diseas[...]

Call for tender - Normal and pathological aging : mechanisms and consequences on population health    University of Lorraine

The goal is to better understand, prevent and treat the increasingly high number of illnesses due to the pathological aging of cells, tissues and organs. In partnership with the University Hospital o[...]

Success Stories - DECIDE: enabling earlier diagnosis of dementia    europa.eu

DECIDE stands for 'Diagnostic Enhancement of Confidence by an International Distributed Environment'. This FP7 project brought together 13 partners from five European countries, with the Italian GARR[...]

Consumer survey of UK kitchens reveals poor food safety perceptions and behaviour in older people    eufic.org

Research conducted by the University of Hertfordshire, UK, and commissioned by the UK Food Standards Agency (FSA), investigated what happens in household kitchens to assess food safety risks in domes[...]

Health literacy of Functional Decline and Frailty related to Ageing – Pilot questionnaire for Older Adult Patients (60+)    cpme.eu

The survey for patients aims to assess the awareness, opinion and attitude of the population aged over 60 regarding healthy and active ageing. The surveys build on the conceptual framework of the Eur[...]

Health Literacy of Functional Decline and Frailty – Pilot Questionnaire for Doctors    cpme.eu

The survey for doctors aims to assess the awareness of doctors on functional performance (/capacity) decline and frailty related to ageing and their possibilities to prevent/ delay the onset of these[...]

Norway should improve incentives to encourage people to work longer, says OECD    oecd.org

Norway is better placed to cope with population ageing than most other countries. But it could still do more to improve incentives and opportunities for people to stay working longer which would help[...]

Commission welcomes final adoption of Directive on supplementary pension rights    europa.eu

The European Commission welcomes the final adoption by the European Parliament of the Directive improving the protection of supplementary pension rights for mobile workers.[...]

Pensions: Commission welcomes final adoption of Directive on supplementary pension rights    europa.eu

European Commission Press release Brussels, 15 April 2014 The European Commission welcomes the final adoption by the European Parliament of the Directive improving the protection of supplementary pen[...]

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