Hospital Sant Joan de Déu and University of Barcelona are looking for a highly motivated candidate with excellent CV and the ambition to pursue a scientific career to apply to Doctoral fellowships from Brazilian Funding Agencies, such as CNPq, CAPES, or FAPS, to work at Hospital Sant Joan de Déu-Universitat de Barcelona, Barcelona, Spain, under the supervision of Dr. Josep C Jimenez-Chillaron.
WHO? highly motivated candidates holding a University degree in Biochemistry, Biology or any related area of Life Science. Candidates with experimental expertise in Biochemistry, Molecular Biology, high throughput sequencing technologies and Bioinformatics analysis are desired. Successful applicants are expected to work in an interdisciplinary team, managing multiple tasks, having good organizational skills, and willingness to work outside their core expertise. Good knowledge of both spoken and written English is required.
Epidemiological evidence shows that sub-optimal nutrition during early development increases risk for chronic non-communicable diseases, including obesity, insulin resistance, type 2 diabetes or cardiovascular disease. In addition, developmental programming of disease risk may be inherited into the following generation offspring through non-genomic mechanisms.
The laboratory is interested in understanding how environmental factors (nutrition) during early mammalian development influence phenotypic variance (disease risk; diabetes) on exposed individuals and their progeny. Epigenetic mechanisms may link early nutritional imbalances with permanent changes in gene expression that lead to adult disease risk. Likewise, epigenetic mechanisms may also mediate nutritionally-induced inheritance of such phenotypes if the epigenetic alterations occur in cells from the germ line.
They have previously developed a mouse model of transgenerational non-genomic inheritance of diabetes risk by neonatal malnutrition. The team is currently investigating the potential role of DNA methylation and small non-coding RNAs in mediating disease risk and transgenerational effects.
List of recent related publications
Jimenez-Chillaron et al., Epigenetics, 2015
Martinez et al., Cell Metabolism, 2014
Radford et al., PLoS Genetics, 2012
Pentintat et al., Endocrinology, 2010
Jimenez-Chillaron et al., Diabetes, 2009
Interested candidates are strongly advised to submit a covering letter and CV to Dr. Jimenez-Chillaron, firstname.lastname@example.org, including
1. List of publications and communications
2. Brief statement of research interests and career goals
3. Names and contact information of at least two referees
More information can be obtained from Dr. Jimenez-Chillaron upon request.
Nr of positions available : 1
Biochemistry, Molecular Biology, Epigenomics, Diabetes, Nutrition
Early Stage Researcher (Pre-Doc)
Hospital Sant Joan de Déu and University of Barcelona provide superb facilities and opportunities for professional development.