Job details

Job posted by Utrecht University (18/08/2014 16.22)

Marie Curie Actions funded job vacancy 'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers PhD Student position in biomolecular NMR

Please note that the job is no longer active!

One PhD position is available in the NMR Spectroscopy Group at the Bijvoet Center for Biomolecular Research, Utrecht University, Netherlands, as part of the Marie-Curie ITN project Manifold.


Project description
The regulation of chromatin structure plays a pivotal role in transcription, DNA replication and repair. This involves a special class of chaperones, the histone chaperones that mediate the correct assembly and disassembly of the nucleosome, the fundamental repeating unit of chromatin. Detailed knowledge on the mode of action of these chaperones is of great interest, not only from a fundamental, but also a biomedical perspective.

This project aims to decipher the molecular basis of chaperone-mediated nucleosome assembly/disassembly, focussing on structural and dynamical consequences on the nucleosome, and the structural basis of chaperone–nucleosome interaction. To tackle these complex systems, the main experimental technique will be advanced solution NMR, complemented by various biochemical essays.

Key publications
• van Ingen et al. (2008), Structure 16, 1245-1256.
• van Nuland et al. (2013), Epigenetics & Chromatin 6, doi: 10.1186/1756-8935-6-12.
• van Ingen and Bonvin (2014), J. Magn. Reson. 241, 103-114.

The position is part of the Innovative Doctoral Programme "ManiFold" - an interdisciplinary Initial Training Network funded by Marie-Curie Actions. You will be part of a team together with 10 other international students. (

Applicants must meet the requirements of EU Marie Curie fellowships/ studentships. They must not have carried out their main activities in The Netherlands for more than 12 months in the 3 years prior to the start of the fellowship. Applicants are expected to hold a degree (e.g. Master of Science or an equivalent diploma) which qualifies them to embark onto a doctoral degree.

Utrecht University
Utrecht University is one of Europe’s leading research universities, recognised internationally for its high quality and innovative approach to both research and teaching. Founded in 1636, the University has always focused strongly on research. Owing to its solid grounding in discipline-based scholarship, Utrecht University is at the forefront of developments in interdisciplinary knowledge. The University participates in various thematic multidisciplinary collaborations that conduct excellent research. With its prominence in teaching and research, Utrecht University works towards finding solutions of the highest possible impact and significance to the major challenges facing the 21st century.

Bijvoet Center
The Bijvoet Center for Biomolecular Research aims to gain insight into the relation, at the molecular level, between the structure and the function and activity of biomolecules that are involved in recognition, interaction, and regulatory processes. To achieve this goal, the Bijvoet Center for Biomolecular Research maintains an advanced infrastructure and provides high-quality research training programs for young scientists.

Nr of positions available : 1

Research Fields

Chemistry - Biochemistry

Career Stage

Early stage researcher or 0-4 yrs (Post graduate)

Research Profiles

First Stage Researcher (R1)


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Other job details
Job ID




Type of Contract





Utrecht University

Hours Per Week


Postal Code





Padualaan 8

EU Research Framework Programme
Is the job funded through the EU Research Framework Programme?

FP7/People - Marie Curie Actions

Project's Marie Curie Grant Agreement Number

ITN 371317

Utrecht University

Bijvoet Center for Biomolecular Research
Padualaan 8
3584CH - Utrecht