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Job posted by University of East Anglia (11/08/2014 16.28)

'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers Protein-Ligand Interactions by Quantitative STD NMR Spectroscopy (ANGULOU15SF)

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This project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.


The specific interactions between biomolecules in solution by non-covalent forces represent the fundamental basis of molecular recognition processes in biology. The specificity comes from structural and functional complementarities between the chemical groups of the participant molecules. NMR spectroscopy has demonstrated its suitability to provide such structural information at atomic level and many experiments have been developed and applied, in particular to receptor-ligand interactions of biological relevance.
Among the NMR techniques based on the observation of ligand signals, saturation transfer difference (STD) NMR in particular has become one of the most powerful and versatile one, with growing applications both in academic research as well as in pharma industry as base strategy in drug discovery, design and optimization. Since its proposal, a number of new implementations have been described (e.g. the use of heteronuclei either at natural abundance or in isotopically enriched samples) which have extended the applicability of this robust and useful technique.
Quantitative STD NMR refers to the accurate correlation of NMR observables with the 3D structure and the kinetics of a given protein-ligand intermolecular complex. The current approaches involve the collection of different set of experiments (STD build-up curves) and using 3D molecular models (from modeling, X-ray diffraction, etc…) to compute theoretical outcomes, by employing full relaxation matrix calculations.
This project will involve the development of new implementations and protocols for reducing significantly the amount of experimental data to be collected, as well as the computational level required, to allow a full quantitative STD NMR study to be carried out in a much shorter time. The selected candidate will work in well-equipped laboratories, with access to state of the art High Performance Computing Cluster (302 node cluster providing a total of 4148 cores) and powerful NMR equipment (800 MHz, 2x 500 MHz, 2x 400 MHz, and 300 MHz spectrometers, equipped with different liquid-, solid-state, and HR-MAS probe heads), in a highly stimulating scientific environment that includes collaboration with internationally distinguished scientists at the University and the wider Norwich Research Park (NRP).

Nr of positions available : 1

Research Fields

Pharmacological sciences - Other

Career Stage

Early stage researcher or 0-4 yrs (Post graduate)

Research Profiles

First Stage Researcher (R1)

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University of East Anglia, Norwich Research Park, Norwich


University of East Anglia

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EU Research Framework Programme
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University of East Anglia

School of Pharmacy
University of East Anglia, Norwich Research Park, Norwich
NR4 7TJ - Norwich