Job details

Job posted by AcademicTransfer (12/07/2014 02.01)

PhD Student 'targeted and personalized cancer therapy development by high-dimensional data analysis'

Please note that the job is no longer active!

Use your quantative modeling skills to enable development of new statistical models and analysis tools and help improve targeted and personalized therapy.

The project:

Joint statistical analysis of multiple -omics data can unravel genomic networks but, as it involves more variables than samples, requires new methods. Previously we developed a powerful model to test for associations (the 'needles') between genome-wide gene expression and copy number (the 'haystack'), producing lists of genes regulated by copy number change (Menezes et al., BMC Bioinformatics, 2009). However, methods to find types of regulatory mechanisms still lack, such as when two or more molecular mechanisms work in different ways to affect gene expression. Understanding regulatory mechanisms in cancer is especially important for targeted and personalized therapy development. For more information about our department, see

Your challenge:

As a PhD Student your main tasks and responsibilities are:

Develop statistical methods and tests to find specific types of gene expression regulation, using multiple high-dimensional datasets simultaneously;

Develop methods, based on tests and/or estimation, that can find specific types of joint effects of covariate sets (molecular profiles) on the response (gene expression);

Analyse the data and write scientific publications which lead to your thesis.


We are searching for a PhD Student who has the following expertise:

A MSc in either Mathematics, Statistics, Bioinformatics or a closely related discipline;

You have a strong background in quantitative modeling including, ideally, either statistics or mathematics; 

You have programming skills, preferably in R;

You can explain complex ideas to biologists/non-specialists;

You have good communication skills, you are self-disciplined and you can work in a multi-disciplinary environment.

Nr of positions available : 1

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields


Career Stage

Early stage researcher or 0-4 yrs (Post graduate)
Experienced researcher or 4-10 yrs (Post-Doc)
More Experienced researcher or >10 yrs (Senior)

Research Profile

Not defined


Salary Scale: OIO (EUR 2.200 in the first year that increases to EUR 2.818 gross per month in the fourth year, based on 36 hours per week).

We also offer a set 8.3% end-of-year bonus and 8% holiday pay. For more information about our fringe benefits, please visit (Dutch version). The PhD position is for four years, you will start with a contract for 12 months.

For more information about the application procedure, please contact Mr. Wessel Haytink, recruiter, at +31(0)6 - 1066 7718.


2200 - 2818


Required Research Experiences
Main Research Field Physics
Required Languages
Language ENGLISH
Language Level Good
Required Education Level
Degree Field Physics
Degree Field Technology
Degree Other
Degree University Graduate
Required Research Experiences
Years of Research Experience 1
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