PhD Position - Elaboration of new classification of autoimmune disease
The Laboratory of Excellence (Labex) IGO and Région Bretagne finance a PhD position : Elaboration of new classification of autoimmune diseases based on bioinformatics analysis of flow cytometry data
Description of recruiting organization:
The Laboratory of immunology, pathology and immunotherapy EA2216, INSERM ERI29 is located at the University Hospital of Brest, France. Its area of research is focused around the B cells in humans. Based on in vitro approaches, the research activity is aimed to understand the physiology of the B cells and the multi-functional aspects that they can have. In addition, in collaboration with the departments of rheumatology, hematology and nephrology of the University Hospital, the laboratory of immunology, pathology and immunotherapy seeks to better understand the role of B cells in the pathophysiology of autoimmune and inflammatory diseases, in chronic lymphocytic leukemia and transplant rejection. Finally, the longer-term objective is the development of new immunotherapy approaches targeting the B lymphocytes.
Our research in immunopathology is developed from basic approaches (epigenetics in autoimmunity, cytokine involvement of BAFF, calcium signaling and regulator B cells) to clinical applications (multicenter clinical trials, IVIg, development of immunotherapies). Since early 2014, the EA2216 unit is strikingly involved in an "Innovative Medicines Initiative" called PRECISESADS. The aim of this european project is to establish a molecular re-classification of autoimmune diseases to ultimately determine novel therapeutic targets.
Description of the position to fill:
The systemic autoimmune diseases are a group of chronic inflammatory diseases whose diagnoses are difficult to establish and the treatments uncertain. Their common feature is the presence of autoantibodies (directed against components of the Self) in the serum. Three diseases are prototypes of those systemic autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, and scleroderma. These three diseases have significant overlap in their events. Several other entities and syndromes can be associated with them such as Sjogren's syndrome and antiphospholipid syndrome. While each clinical entity can be considered as "rare", the whole constitutes the third leading cause of morbidity throughout the world (1% of the general population). In addition, there are many people who do not meet clinical criteria or who do not share all the characteristics of either of these diseases and in fact, live for years as "undifferentiated case ". This PRECISESADS project aims to use the power of "omics" techniques (genomics, transcriptomics, epigenomics, metabolomics, proteomics), and bioinformatics to develop new molecular taxonomy to be able to re-classify the diseases known to share common pathophysiological mechanisms.
In this context, the PhD student will have to investigate the data generated by flow cytometry analyses of all the patients included in the PRECISESADS project. He (she) will have the assistance of a computational engineer.
Nr of positions available : 1
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Technology - Biotechnology
Early stage researcher or 0-4 yrs (Post graduate)
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