return

Job details

Job posted by Academic Positions (18/04/2014 17.33)

Phd, How do targeted vessel occlusions impair brain microcirculation? Numerical modeling and experimental validation

This PhD position is part of the interdisciplinary Brain MicrThis PhD position is part of the interdisciplinary Brain Micro Flow project (2014-2019) awarded to Sylvie Lorthois (www.imft.fr/LORTHOIS-Sylvie,126) under the European Research Council Consolidator grant scheme (http://erc.europa.eu/consolidator-grants). Her group at the Institut de Mécanique des Fluides de Toulouse focuses on modelling the structure and function of brain microcirculation at various scales. o Flow project (2014-2019) awarded to Sylvie Lorthois

Description

PhD position at the Centre National de la Recherche Scientifique,
Institut de Mécanique des Fluides de Toulouse (UMR CNRS-INPT-UPS 5502)

How do targeted vessel occlusions impair brain microcirculation?
Numerical modeling and experimental validation

Keywords: Biofluid Mechanics, Porous Media, Blood microcirculation, Microvascular Networks, Transport, Transfers.

Academic context: This PhD position is part of the interdisciplinary Brain Micro Flow project (2014-2019) awarded to Sylvie Lorthois (www.imft.fr/LORTHOIS-Sylvie,126) under the European Research Council Consolidator grant scheme (http://erc.europa.eu/consolidator-grants). Her group at the Institut de Mécanique des Fluides de Toulouse focuses on modelling the structure and function of brain microcirculation at various scales. The Brain Micro Flow project also involves the Department of Biomedical Engineering of Cornell University (USA) for advanced in vivo optical imaging and manipulation of cerebral blood flow and the INSERM "Cerebral Imaging and Neurological Handicaps Laboratory", Toulouse, for its unique expertise in human intra-cortical micro-anatomy.

Scientific context: The cerebral microvascular system is essential to a large variety of physiological processes in the brain, including blood delivery and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It plays a major role in the associated processes leading to disease (stroke, neurodegenerative diseases) but the comprehension of the basic mechanisms involved is still largely incomplete. In the last decade, cutting edge experimental technologies, including two-photon scanning laser microscopy (TPSLM) and optically-induced single-vessel occlusions, have produced huge amounts of anatomic and functional experimental data in normal and Alzheimer Disease (AD) mice. These require accurate, highly quantitative, physiologically informed modeling and analysis for any coherent understanding and for translating results between species.

Nr of positions available : 1

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields

Neurosciences
Engineering - Biomedical engineering
Biological sciences

Career Stage

Early stage researcher or 0-4 yrs (Post graduate)

Research Profiles

Not defined


GET MORE! The EURAXESS Services Centres
 

To better plan and organise their stay in a foreign European country, researchers and their families can also benefit of the free and personalised assistance offered by the EURAXESS Services Centres, a network of more than 200 centres located in 40 different European countries.

Apply

Application Deadline

31/10/2014

Other job details
Logo
Job ID

33920654

Country

FRANCE

Type of Contract

Temporary

Status

Full-time

Street

3, rue Michel-Ange

Postal Code

F-75794

Company/Institute

CNRS National Center for Scientific Research

City

Paris

Company/Institute
CNRS National Center for Scientific Research

Other
3, rue Michel-Ange
F-75794 - Paris
FRANCE
email info@academicpositions.euhttp://www.cnrs.fr/index.php