Phd, Red blood cell suspensions flowing in micro-channel networks: heterogeneities and network effects
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This PhD position is part of the interdisciplinary Brain Micro Flow project (2014-2019) awarded to Sylvie Lorthois (www.imft.fr/LORTHOIS-Sylvie,126) under the European Research Council Consolidator grant scheme (http://erc.europa.eu/consolidator-grants).
PhD position at the Centre National de la Recherche Scientifique,
Institut de Mécanique des Fluides de Toulouse (UMR CNRS-INPT-UPS 5502)
Red blood cell suspensions flowing in micro-channel networks: heterogeneities and network effects
Keywords: Biofluid mechanics, Microfluidics, Blood microcirculation, Porous Media, Dense suspension flows, Phase separation effect, Dispersion.
Academic context: This PhD position is part of the interdisciplinary Brain Micro Flow project (2014-2019) awarded to Sylvie Lorthois (www.imft.fr/LORTHOIS-Sylvie,126) under the European Research Council Consolidator grant scheme (http://erc.europa.eu/consolidator-grants). Her group at the Institut de Mécanique des Fluides de Toulouse focuses on modelling the structure and function of brain microcirculation at various scales. The Brain Micro Flow project also involves the Department of Biomedical Engineering of Cornell University (USA) for advanced in vivo optical imaging and manipulation of cerebral blood flow and the INSERM "Cerebral Imaging and Neurological Handicaps Laboratory", Toulouse, for its unique expertise in human intra-cortical micro-anatomy.
Scientific context: The cerebral microvascular system is essential to a large variety of physiological processes in the brain, including blood delivery and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It plays a major role in the associated processes leading to disease (stroke, neurodegenerative diseases) but the comprehension of the basic mechanisms involved is still largely incomplete, partly due to the lack of accurate, physiologically informed modeling and analysis validated against quantitative experimental data. In particular, one of the main scientific challenges is to model the strong coupling between microvascular architecture and blood flow dynamics. For that purpose, model experiments performed in micro-channel networks under finely controlled conditions mimicking the physiologic regimes are needed.
Nr of positions available : 1
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Engineering - Biomedical engineering
Early stage researcher or 0-4 yrs (Post graduate)
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