IESR5 The extended DISC1 interactome
One ESR Marie Curie training position is available at the Department of Molecular and Cellular Neurobiology at the Center for Neurogenomics and Cognitive research (www.cncr.nl) in the team of Guus Smit and Ka Wan Li.(email@example.com).
Responsibilities and tasks
Dysfunctions in synaptogenesis and synaptic transmission play a key role in the etiology of SCZ. This project focuses on the identification of synaptic proteins and complexes of proteins that are playing a role in synaptic signalling in mouse models related to an aberrant extended DISC1 pathway, using a wide spectrum of biochemical analysis techniques and a subsequent functional analysis, i.e., from proteins / proteomics to synapses to behaviour.
Specific project aims are:
1) Identify proteins dysregulated in different animal models of SCZ,
2) determine protein interactors of the main protein hubs in SCZ by means of proteomics analysis,
3) determine the shifts in activity dependent composition of protein complexes (interactome) in cortical synapses and in SCZ mouse models,
4) comparative bioinformatics analysis with data of other animal models of brain disease (present in the database of the CNCR)
We will use LC-MS/MS based (interaction) proteomics to identify the protein complexes and their quantitative changes in SCZ mouse models.
At the date of appointment, candidates must have obtained, or finalize within 5 months, a Master's (M.Sc.) degree in Neuroscience or a similar degree with an academic level equivalent to the Master's degree in Neuroscience. For selection of the applicant we will look into the relevance of the applicant’s research to the doctoral program he or she is applying for, earlier research achievements, and the motivation letter. Solid written and oral communication skills in English are prerequisites of any successful application.
• Master’s degree (or equivalent) in Neuroscience
• Previous lab experience in molecular biology and protein analysis.
• A good command of English language
Nr of positions available : 1
Neurosciences - Neurobiology
Early stage researcher or 0-4 yrs (Post graduate)
First Stage Researcher (R1)
Comment/web site for additional job details
To better plan and organise their stay in a foreign European country, researchers and their families can also benefit of the free and personalised assistance offered by the EURAXESS Services Centres, a network of more than 200 centres located in 40 different European countries.
De Boelelaan 1085
FP7/People - Marie Curie Actions
Publish your job vacancies & fellowship programmes or Post your CV