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Job details

Job posted by University of East Anglia (11/12/2013 16.12)

'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers Targeting non-canonical DNA structures in the genome

This project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources.

Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees. A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.

Description

It is assumed that DNA exists as a Watson-Crick double helix in cells but DNA has also been shown to be highly polymorphic. Alternative DNA structures can form, depending on the sequence and local environment conditions. It has been indicated that some structures could have biological functionality. For example, G-quadruplexes formed from G-rich sequences have been shown to play a role in gene function, i.e. switching genes on or off and have recently been shown to exist in the nucleus and cytoplasm of human cells. There is mounting evidence that the human genome is full of lots of different types of secondary structures and recently it was suggested that there is an alternative layer of genetic code hidden in these constructs. This project will involve the creation of novel types of molecules to interact with higher order nucleic acid secondary structures which we can then use as chemical biological probes. The work will be interdisciplinary, at the chemistry-biology interface, and will involve a combination of chemical synthesis, biophysics and molecular biology.

Nr of positions available : 1

Research Fields

Pharmacological sciences

Career Stage

Early stage researcher or 0-4 yrs (Post graduate)

Research Profile

First Stage Researcher (R1)

Benefits

Primary Supervisor:
Dr Zoë Waller
Email: z.waller@uea.ac.uk

Comment/web site for additional job details

http://www.uea.ac.uk/study/postgraduate/research-degrees/science/pharmacy




Requirements

Required Languages
Language ENGLISH
Language Level Good
Required Education Level
Degree Field Pharmacological sciences
Degree Primary Degree or equivalent
Additional Requirements
Those applicants whose first language is not English must demonstrate evidence of appropriate English language proficiency, normally defined as a minimum IELTS score of 6.5 (Overall Band Score) with 6.0 in all elements or equivalent.
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Application website

http://www.uea.ac.uk/study/postgraduate/apply

Application Deadline

31/07/2014

Other job details
Job ID

33893587

Country

UNITED KINGDOM

Type of Contract

Other

Status

Other

Company/Institute

University of East Anglia

Street

School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich

Postal Code

NR4 7TJ

City

Norwich

EU Research Framework Programme
Is the job funded through the EU Research Framework Programme?

No

Company/Institute
University of East Anglia

School of Pharmacy
Academic
School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich
NR4 7TJ - Norwich
UNITED KINGDOM
email pgr.enquiries.admiss@uea.ac.ukhttp://www.uea.ac.uk/study/postgraduate/apply

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