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Bio-inspire is a Marie Curie Initial Training Network (ITN) on bone regenerative therapies. In BIO-INSPIRE, a technology platform will be developed for full tissue regeneration of a range of critical sized bone defect types. This platform consists of a new recombinant collagen biomaterial scaffold, that will be used (1) as a bio-mimetic mineralised scaffold, (2) as a local delivery system for growth factors and (3) as a delivery system for (autologous) cells.
The consortium consists of an alliance of careful selected partners with a high reputation in a set of complementary disciplines consisting of Fraunhofer, Medicyte, Germany (cell therapy), Fujifilm Life Science, Tilburg, the Netherlands (biomaterials), ISTEC, Feanza, Italy (bone mineralisation), Erasmus MC University Medical Center Rotterdam, the Netherlands (growth factors), University of Bologna, Bone Therapeutics, Italy (orthopaedic therapy). The network offers a total of 11 Early Stage Research (ESR) PhD positions for 36 months and 5 Experienced Researcher (ER) post-doctoral positions for 14 to 24 months.
Natural bone tissue repair is triggered amongst others by the presence of growth factors at the repair site. To enhance bone repair BMPs have been injected at the repair site or have been added to scaffolds placed at the repair site. However the effect of BMP release profile has not been well studied. Fujifilm developed a new biodegradable recombinant collagen-like protein (RCP) that has proven to be very suitable in various medical devices. In this project the RCP will be used to create an (injectable) controlled release system for growth factors and peptides. More specifically it is the aim to develop a toolkit of chemical modifications of this RCP for tuning release patterns. Functionality will be evaluated with various assays for cell migration, bone formation and angiogenesis in vitro and in vivo.
You should have a concluded Masters Degree in the field of Biology, Biomedical Science or Technology, Medicine or a comparable study. Affinity with biomaterials research is required. Experience with set-up and evaluation of in vitro cell culture and in vivo experiments is a pre. Good communication skills and proficiency in english are required.
PhD position for 36 months at the host institute Erasmus MC University Medical Center in Rotterdam the Netherlands (under the supervision of Prof. dr. G.J.V.M. van Osch, Prof dr JPTM van Leeuwen and dr. E. Farrell) with a total of approx.. 6 month visits to the German and/or Italian partners. This PhD position is closely related to the PhD position ESR4 at the Fraunhofer institute.
Please note that the eligibility requirements of the Early Stage Research (ESR) PhD positions are very rigid. Please ensure that you qualify before applying as ineligible candidates cannot be considered. The network encourages particularly women to apply.
• Applicants should not have resided or performed their main activity in the country of the host institution for more than 12 months in the 3 year period immediately prior to the start date of the fellowship.
• Applicants for the Early Stage Research (ESR) PhD fellowships should be in the first 4 years (full-time equivalent) of their research careers, including the period of research training, starting at the date of obtaining the degree which would formally entitle them to embark on a doctorate.
How to apply
Applications should submit a personal statement explaining their motivation, a CV and possible references. The project will start from October 2013 onwards. The envisioned starting date for this position is June 2014. Applications can be sent to email@example.com
Nr of positions available : 1
Early stage researcher or 0-4 yrs (Post graduate)
First Stage Researcher (R1)
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dr Molewaterplein 50-60
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