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BCR/ABL1+ acute lymphoblastic leukemia is a subgroup whose incidence increases with age (>50% in elderly).
Though the outcome of BCR/ABL1+ cases dramatically improved upon the introduction of tyrosine kinase inhibitors, the only curative option is still represented by allogeneic stem-cell transplantation, which is however aggravated by toxicity/mortality and is not feasible for all patients. Furthermore, a set of patients might be spared this procedure.
Preliminary data suggest that novel copy number aberrations (CNA) have prognostic significance.
To improve risk stratification, currently relying on minimal residual disease and identification of resistant ABL1 mutations, we will: i) screen these novel lesions in a broader cohort of BCR-ABL1+ cases (N=100) by CAN analysis; ii) develop a Droplet-PCR based approach for their identification; iii) validate their association with patients’ outcome; iv) build a predictor model, combining these findings with conventional features.
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Medical sciences - Medicine
Number of awards per year
Frequency of calls
International mobility required ?
Eligible destination country/ies for fellows
Albania, Andorra, Austria, Belarus, Belgium, Bosnia-Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Faroe Islands, Finland, France, FYRoMacedonia, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, MOLDOVA, Monaco, Montenegro, Netherlands, Norway, Poland, Portugal, Romania, Russia, San Marino, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, Ukraine, United Kingdom, Vatican City
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