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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (20/02/2016 03.02)

IDENTIFICATION AND SCREENING OF NOVEL PROGNOSTIC MARKERS IN ADULT BCR-ABL1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Please note that the job is no longer active!

BCR/ABL1+ acute lymphoblastic leukemia is a subgroup whose incidence increases with age (>50% in elderly).

Though the outcome of BCR/ABL1+ cases dramatically improved upon the introduction of tyrosine kinase inhibitors, the only curative option is still represented by allogeneic stem-cell transplantation, which is however aggravated by toxicity/mortality and is not feasible for all patients. Furthermore, a set of patients might be spared this procedure.

Preliminary data suggest that novel copy number aberrations (CNA) have prognostic significance.

To improve risk stratification, currently relying on minimal residual disease and identification of resistant ABL1 mutations, we will: i) screen these novel lesions in a broader cohort of BCR-ABL1+ cases (N=100) by CAN analysis; ii) develop a Droplet-PCR based approach for their identification; iii) validate their association with patients’ outcome; iv) build a predictor model, combining these findings with conventional features.

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields

Medical sciences - Medicine


Programme Description
Number of awards per year1
Annual budget19367
Frequency of calls1
International mobility required ?no
Eligible destination country/ies for fellowsAlbania, Andorra, Austria, Belarus, Belgium, Bosnia-Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Faroe Islands, Finland, France, FYRoMacedonia, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, MOLDOVA, Monaco, Montenegro, Netherlands, Norway, Poland, Portugal, Romania, Russia, San Marino, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, Ukraine, United Kingdom, Vatican City
Eligibility of fellows: country/ies of residenceE.U.
Eligibility of fellows: nationality/iesE.U.
Website of Fellowship Programmewww.uniroma1.it
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
Total amount per fellowship per year19367
Currencyeuro
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
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Application deadline

18/03/2016

Other fellowship details
EURAXESS ID

95634

Funding organisation / Contacts
DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA

Academic
ROMA - Italy
dbce.uniroma1.it
E-mails
palucci@uniroma1.itPhones
06/49918246

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