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Possible artifactual behaviours of individual cells in 2D, as compared to 3D, stimulate the creation of 3D artificial environments that mimic the physiological environment experienced by cells in any multicellular organisms. We have recently developed a novel protocol of liquid core hydrogel capsule formation well suited for cell culture. For the present project, we wish to implement an extracellular matrix in the core that embeds cholangiocytes, the epithelial cells of the bile duct. One of the objectives is to decipher the role of a protein during the formation of cysts with a central lumen, and more generally its implication in epithelium features. Moreover, the role played by the mechanical features of the ECM on the tissue fate will be assessed. The postdoc will thus have the mission to create capsules having a gelled core with controlled properties and to monitor the development of tissue formation. The encapsulation approach will allow to parallelize tissue growth observation.
We look for a candidate having accomplished a PhD in cell biology, or in biophysics, who is motivated by such a multidisciplinary project. Strong skills in cell culture, live cell imaging, extra cellular matrix reconstruction are desired. Knowledges in histology, physico-chemistry of soft matter and micro-fabrication are welcomed.
A motivation letter and a CV, including referent persons or letters of reference, should be sent to Nicolas Bremond (firstname.lastname@example.org). For more information: 01 40 79 52 34.
International mobility required ?
Eligible destination country/ies for fellows
Eligibility of fellows: country/ies of residence
Eligibility of fellows: nationality/ies
Experienced researcher or 4-10 yrs (Post-Doc)
Recognised Researcher (R2)
Employment contract with full social security
Maximum duration of fellowship
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