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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (30/08/2014 02.46)

Molecular bases of amyloidogenic proteins aggregation

Please note that the job is no longer active!

The principal aims of this research project are as follows:

1. Characterization of anatomical, biological and physical-chemical factors responsible for the tissue specificity of amyloid deposition in systemic amyloidosis.

2. Elucidation of the mechanism by which natural extracellular chaperones and other tissue components can modulate the amyloid formation in vivo. Preliminary data obtained with the first natural amyloidogenic variant of β2-

microglobulin (D76N) show that amyloid

fibrillogenesis is strongly enhanced by

hydrophobic surfaces, including ubiquitous

constituents of the extracellular matrix in the interstitial space, such as elastin and

proteoglycans. In contrast, known extracellular chaperone proteins can potently inhibit fibril formation. This research project intend to determine how these opposite effects can modulate amyloid deposition in vivo.

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields

Biological sciences

Eligibility criteria

The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: http://www.unipv.eu/on-line/Home/Ricerca/Assegnidiricerca.html.

Main requirements are:1) degree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D.M. n. 509/1999) or post-graduate degrees (pursuant to D.M. n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent - for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment; 2) scientific or professional curriculum suitable for conducting the research activity; 3) Ph.D. title (Art 2- par. 1).

Selection process

The application form, signed in original, have to be: 1) submitted by means of the standard template that can be found at the above address; 2) supplied with the scientific-professional curriculum vitae (dated and signed) and a photocopy of a valid identity document; 3) supplied with the list of publications and copies of them (or in electronic form); 4) supplied with any further documents / certificates / self-certification foreseen by Art. 4; 5) sent (no e-mail, no website) via recorded delivery, via a Certified Email (PEC) and by hand, in original paper copy, to the Department/Centre of interest (see Art. 4). The candidate selection will take place on the basis of the documented qualifications and a personal interview, completed by a test concerning the knowledge of foreign language (see Art. 6 - par. 1)


Programme Description
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programmehttp://www.unipv.eu/site/home/ricerca/assegni-di-ricerca.html
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
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Application deadline

06/10/2014

Other fellowship details
EURAXESS ID

74254

Funding organisation / Contacts
Università degli studi di Pavia

Public research
Pavia - Italy
http://www.unipv.eu/site/home.html
E-mails
antonella.piro@unipv.itemdip09@unipv.itstoppini@unipv.itPhones
0382 987784
0382 987232
0382 987189

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