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Psoriasis affects the 2-5% of the general population at any age, in particular from 15 to 50 years old. From an hystological point of view psoriasis is characterized by acantosis, parakeratosis and dermal infiltration of T-lymphocytes, dendritic cells and monocytes/macrophages. Neutrophils infiltration and elongment of dermal papillae may also be present. These cells are able to produce different types of cytokines, which contributes to the development of the psoriatic plaques. Psoriasis is now considered a Th1/Th17 mediated dermatosis with an increas of the associates cytokines. IL-23 which is produced by dendritic cells and macrophages, is able to induce the expression of TNF-alpha and IL-22. TNF alpha is involved in the regulation of keratinocytes proliferation and is able to induce the production of many other cytokines. Dermal macrophages are the principal source of TNF-alpha.
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