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The aim of the study is to evaluate the circulating levels of cardiotrophin1 and of several biomarkers of collagen synthesis /degradation in a group of patients with preserved or reduced systolic function, enrolled at Clinica Medica -2a Medicina Spedali Civili Brescia. The detailed phenotyping of these patients will allow a more precise effect of exercise training on cardiovascular abnormalities that are usually associated to heart failure with preserved or reduced ejection fraction.
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