'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers.
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The project will be focused on the characterization of PINK1, a kinase protein mutated in autosomal recessive Parkinson's disease (PD), known to prevent mitochondrial damage and apoptosis and to regulate mitochondrial dynamics and mitophagy. It is known that PINK1 interacts with Beclin1, positively regulating the autophagy and with Bcl−xL, a key antiapoptotic protein implicated in regulation of mitochondrial homeostasis and synaptic plasticity. The candidate will investigate the functional role of PINK1 interactions on autophagic and apoptotic pathways and will characterize the subcellular sites where this interactions take place, through a range of complementary in vitro and in vivo techniques. Experience in techniques of co-immunoprecipitation, subcellular fractionation and confocal microscopy is especially requested.
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Number of awards per year
International mobility required ?
Eligible destination country/ies for fellows
Albania, Andorra, Austria, Belarus, Belgium, Bosnia-Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Faroe Islands, Finland, France, FYRoMacedonia, Germany, Greece, Hungary, Iceland, Ireland, Italy, Italy, Latvia, Liechtenstein, Lithuania, Luxembourg, Malta, MOLDOVA, Monaco, Montenegro, Netherlands, Norway, Poland, Portugal, Romania, Russia, San Marino, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Switzerland, Turkey, Ukraine, United Kingdom, Vatican City
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