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Current, advanced studies of PK genes are based on the integration of clinical, genetic/biological, functional, and structural/computational approaches to characterize underlying molecular signatures of cancer mutations. The present research proposal aims at fostergin the existing integrated cancer research workflow among the group MOSE at University of Trieste (UniTS, Italy), the MD Anderson Cancer Center at Houston (TX, USA), the University of Michigan (Ann Arbor, MI, USA), the International Center for Genetic Engineering and Biotechnology (ICGEB, Trieste) and Structural Biology Unit at Elettra-Synchrotron Trieste S.C.p.A. (Italy).
The role of our MOSE computational facility at UniTS will be perform a through in silico structural and energetical characterization of all the detected BCR-ABL single/polymytants and will formulate a rationale for possible mechanisms of PK activation and/or resistance to selected TKIs by said cancer mutations.
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