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Skeletal disorders and obesity are degenerative diseases causing progressive disability and are becoming more prevalent in our society. Precursor cells in peripheral blood can be analyzed to reveal differentiation process alterations associated to specific degenerative diseases. We postulate that gene expression alteration during differentiation process may disrupt the balance between osteo and adipo progenitors in osteoporotic patients with respect to patients with obesity and normal individuals. This aspect represents an interesting link between the two different pathologic settings and the analysis of transcriptomic profile in circulating mesenchymal stem cells of patients represents an original and minimally invasive approach. Gene expression can be studied by next-generation sequencing methods that provide cheap and reliable large-scale DNA and RNA sequencing.
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Medical sciences - Medicine
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