Fellowship & Grant details

Fellowship posted by AMBER-ITN (14/02/2014 14.39)

Marie Curie Actions funded fellowship Marie-Curie ITN AMBER: One Early Stage Researcher (PhD) position in Molecular Bacteriology at INRA, Paris, FRANCE

Please note that the job is no longer active!

AMBER is setup to provide a comprehensive, timely and multidisciplinary training in microbiology for young European researchers, 8 Early Stage Researchers and 2 Experienced Researchers. We have brought together 9 EU partners and 1 associated partner, including 3 companies. We will investigate an important and multifaceted bacterial problem: the intertwinement of central carbon metabolism and main cellular processes. The model system that we will use is the bacterium B. subtilis. The network comprises of 9 full partners (7 academic and 2 industrial) and 1 associate partner.

Research Fields

Biological sciences - Biology

Eligibility criteria

Candidates should comply with the rules for Marie Curie early-stage researchers. One of these rules is that the fellows to be appointed must not have resided or carried out their main activity in the host organisation's country for more than 12 months in the 3 years immediately prior to the appointment date. Short stays such as holidays are not taken into account.

TITLE: interplay between metabolism, signaling and replication initiation control in Bacillus subtilis.
SUPERVISOR: Dr Marie- Françoise Noirot-Gros

BACKGROUND: B. subtilis DNA replication is known to be under metabolic control, and this is well documented for the control of replication elongation by the stringent response. The frequency of initiation of DNA replication is another key parameter determining the rate of DNA synthesis in the cell, which is tightly coupled to growth. Yet, checkpoints that couple initiation firing to the cellular metabolic status remain to be discovered. In B. subtilis, initiation control is mainly exerted by YabA which negatively regulates the activity of the initiator DnaA. In a network of protein-protein interactions YabA appears connected with proteins regulated by carbon catabolite repression effector, and with proteins involved in chemotaxis and signaling. Thus, these PPIs might serve to “inform” YabA of the metabolic status of the cell, providing a potential signalling pathway for the coupling of chromosomal replication initiation with central carbon metabolism. The PhD student will address the regulatory interplay between the cellular metabolism and chromosomal replication initiation. The main angle to tackle this question will be to study the signal that informs the initiation controller YabA of the cellular metabolic status through protein-protein interactions. The early stage research fellow will gain the appropriate skills in molecular genetics, molecular biology and genomic techniques. He/she will have access to research facilities (transcriptomic, proteomic, robotic and microscopic plateforms) available at INRA.

WE SEEK an outstanding and highly motivated candidate to fill this PhD position at the INRA of Jouy, France. Candidate must hold a master degree in Biology, Microbiology, Biochemistry, or related fields and have a strong interest in bacterial cell biology. Master degree must have been obtained less than 4 years at the time of appointment. He must have some laboratory experience in molecular biology, genetics, microbiology or biochemistry. Some experience in bioinformatics or microscopy and imaging techniques would be an advantage. Team-work skills and a desire to work on interdisciplinary projects are also a prerequisite. The candidate can be of any nationality, but < 1 year living/working in host country since 3 years before appointment. The fellowship is based on a 3-year (36 months) contract. Starting date for appointment: March 2014.

HOW TO APPLY: please send your CV and a covering letter including the contact details of two referees by e-mail to Dr Marie-Françoise Noirot-Gros (marie-francoise.gros at

Selection process

Within this international training programme, we will investigate the influence of central carbon metabolism on important cellular processes in the bacterial model system Bacillus subtilis, including cell division, stress management, cell wall synthesis, metabolic regulation, metal homeostasis, DNA replication, secondary metabolite production, RNA processing, metabolomics and enzyme
production. This multidisciplinary project provides a unique training environment for ambitious early-stage researchers. Training in transferable skills. Training in secondments, visits and collaboration with both the academic and industrial partners. This all will prepare the researchers for both a successful career in academia as well as in the private sector.

Promising candidates will be interviewed on a first-come first-serve basis. For more information how to apply also look at

Programme Description
International mobility required ?yes
Eligible destination country/ies for fellowsBelgium, France, Germany, Netherlands, United Kingdom
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate), Experienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesFirst Stage Researcher (R1), Recognised Researcher (R2)
GET MORE! The EURAXESS Services Centres

To better plan and organise their stay in a foreign European country, researchers and their families can also benefit of the free and personalised assistance offered by the EURAXESS Services Centres, a network of more than 200 centres located in 40 different European countries.

Application deadline


Application website

Other fellowship details


EU Research Framework Programme

FP7/People-Marie Curie Actions (except COFUND)

Funding organisation / Contacts

Research Laboratory
Science Park 904 1098 XH Amsterdam - Netherlands