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The main aim of this project consists in the disclosing of the connection between NAFLD and iron metabolism related parameters by measuring serum hepcidin (and other parameters) in patients with NAFLD affected by type 1 diabetes mellitus. We will also evaluate, by mass spectrometry (SELDI-TOF), proteomic profiling and differentially expressed peptides present in patients compared to healthy subjects or controls not affected by diabetes. MOreover we are going to test the conditions to insulin resistance in presence of iron overload in cellular models.
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