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Osteosarcoma is the second cause of cancer death in children and young adults with high frequency of recurrences and metastases even after aggressive chemotherapy or radiotherapy. A small subpopulation of cancer stem cell (CSC) are suspected to be responsible for tumor growth, for high osteosarcoma resistance to anti-cancer treatments and for recurrences and metastases. Targeting these CSCs may result in an effective and complete tumor eradication.
We propose to isolate CSCs from human osteosarcomas, to investigate their phenotype and their cellular and molecular biology, in order to identify specific cellular properties and/or molecular markers that could be used for the design of novel targeted anti-CSC therapies.
We aim to identify miRNAs involved in the maintenance of CSC stem properties and to analyze the effects of their deregulation on CSC phenotype and abilities. Identified miRNAs may be used as molecular targets for the design of novel anti-osteosarcoma therapies
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Medical sciences - Medicine
Curriculum Vitae, Scientific titles and publications, Interview
The competition will be carried out by an evaluation of titles and examination, by means of an interview
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