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Recent data suggest that the precocius exposure of the developing central nervous system to pharmacological or environmental stresses profoundly influences myelination, with permanent effects on cerebral functionality and on the ability to adapt to external stimuli during adulthood. Viceversa, it has been proposed that restoration of proper myelination processes favours functional recovery after injury or stress. The aim of this project is to validate the role of myelination in an animal model of perinatal stress in the rodent, by analyzing the behavior of oligodendroglial precursor cells (OPCs), the myelin-forming cells, in brain sections of mice of various ages and at different times after the stressful stimuli. To this purpose, immunohistochemical techniques and real time PCR will be used to determine distinct OPC maturation stages.
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Pharmacological sciences - Other
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