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Nanoparticles are a class of materials defined by size-dependent properties. Application fields range from medical imaging to new technologies. Due to the expanding use of nanoparticles, the risk of human exposure rapidly increases and toxicity test are urgently needed. Currently, nanoparticle cytotoxicity testing is based on in vitro methods established for hazard characterization of chemicals. Recently, a new test for acute toxicity based on the use of human mesenchymal stem cells (hMSCs) has been developed and successfully tested. The results show that, for the tested substances hMSCs have the ability to correctly predict the GHS hazard category. The grant recipient will have to carry out an activity that concerns the application of this test to evaluate the acute cytotoxicity of a wide range of nanoparticles.
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