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This research project will focus on the development of fluorine-functionalized nanosystems as novel diagnostic and therapeutic tools for the anti-cancer treatment, with particular interest on melanoma. The project will investigate the stability of multi-functional core-shell nanoparticles in biological fluids by light scattering techniques (such as DLS) and small angle neutron scattering techniques (SANS). A protocol to incorporate single o multi anti-melanoma drugs into the nanoparticles will be also developed. Release study in physiological conditions to estimate the efficacy in vivo will be performed by HPLC. Finally, the loaded nanoparticles will be tested on a wide range of melanoma cell lines in collaboration with Dr Sherwood in the School of Pharmacy, UEA, Norwich, UK. Collaborations with specialized Institutes are also established to develop a melanoma mouse model in order to test such nanotherapeutics in vivo.
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In order to participate in the selection, please read the notice of selection (“bando”) available at the following website: http://www.polimi.it/lavora-con-noi/collaborazioni-di-ricerca/assegnidiricerca/
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