Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (04/07/2013 02.21)

Molecular and cellular bases of intestinal mucosal pathology in Omenn Syndrome

Please note that the job is no longer active!

Omenn syndrome (OS) is a rare monogenic disorder characterised by immunodeficiency associated with autoimmune-like manifestations. Studies of patients with OS have provided fundamental information about how their restricted T and B cell repertoire contributes

In the present project, we will investigate to which extent molecular and cellular alterations in mucosal barriers influence immune phenotype and autoimmune signs in OS. In parallel with murine studies, we plan to evaluate human specimens obtained from patients affected by V(D)J recombination defects associated with autoimmune manifestations.

Overall, the results obtained in this integrated grant will be of general significance, allowing us to provide new insights into the mechanisms controlling immune tolerance in primary immunodeficiencies associated with immunological dysregulation, which will be instrumental to improve current therapeutic approaches and to develop innovative therapeutic strategies in autoimmunity.

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Research Fields

Medical sciences

Programme Description
Number of awards per year1
Annual budget€ 15.000
Frequency of calls12 (dodici) mesi
International mobility required ?yes
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Employment contract with full social securityyes
Total amount per fellowship per year15.000
Covers salaryyes
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Application deadline


Other fellowship details


Funding organisation / Contacts
Università degli Studi di Brescia

Public research
Brescia - Italy