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Estrogen receptor alpha controls mammary cell growth and differentiation by profoundly affecting gene transcription and epigenetic status, both in absence and presence of estrogenic hormones. Recently, by means of RNA-Seq we evidenced the regulatory activity of ERα on several hundreds of long noncoding RNAs (lncRNA) of unknown function, in addition to thousands of protein-coding genes and miRNA. In the present project, the regulation and function of some of these lncRNAs will be addressed in depth, by using breast cancer cell lines, where estradiol induces proliferation, whereas downregulation of ERα by RNA interference causes apoptosis and epithelial mesenchymal transition. Studies on lncRNA transcription, Transcription Factor binding and epigenetic marks are planned. In the meanwhile, subtractive and additive experiments will give insight into the function of these selected, ERα regulated lncRNAs.
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The call, the requirements and how to apply are available at the following address: https://www.serviziweb.unito.it/albo_ateneo/
qualifications and interview (in Turin) - Dates and venues of the interviews are published on the website of the University of Turin at the official notice board (https://www.serviziweb.unito.it/albo_ateneo/) by the date of the deadline
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