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Targeting gene expression in tumour cells.
We investigate how oncogenes and tumour suppressors regulate gene expression, currently focusing on the mRNA methyl cap. Despite many recent advances, 50% people diagnosed with cancer survive less than 5 years, and therefore there is an urgent need for new therapeutic approaches. We are investigating the mechanism and regulation of methyl cap synthesis, with the aim of understanding its potential as a therapeutic target. The methyl cap is formed o...
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