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The advent of the Bcr-Abl tyrosine kinase inhibitors (TKI) for the treatment of Chronic Myeloid Leukemia (CML), which act blocking the activity of the BCR-ABL oncogenic protein, has increased the use of the Molecular Biology techniques both for the diagnosis and for monitoring of the response to therapy. The purpose of this project is the detection of Minimal Residual Disease (MRD), by quantitative PCR method (real-time PCR) of the fusion BCR-ABL gene, in CML patients treated with this kind of new generation drugs and correlation with the response to therapy. The aim of this project is also to evaluate if there is a correlation between the BCR-ABL copy number at diagnosis and the response to a specific targeted therapy.
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Medical sciences - Medicine
Vote of Full Degree; Publications ; Ph.D. Diplomas and certificates of attendance of post-graduate courses; Other activities related to the research activity. Interview on the research topic.
ranking obtained by the sum of the scores of titles and the score obtained in the interview
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