Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (10/05/2013 03.05)

Glucagon-like peptide 1 (GLP-1), hexosamine pathway, Endoplasmic Reticulum stress and insulin signal transduction in human umbilical vein endothelial cells (HUVECs)

Please note that the job is no longer active!

The molecular and cellular processes by which chronic hyperglycemia promotes the development and/or the progression of atherosclerosis, have not been fully elucidated yet. One major hypothesis is that hyperglycemia may cause diabetic vascular complications through the hexosamine pathway. Recent data suggest that glucosamine (GlcNAc), may act by concurrently impairing insulin signal transduction and activating the Endoplasmic Reticulum (ER) stress response in HUVECs. Glucagon-like peptide 1 (GLP-1) analogues-based therapies are a new option for type 2 diabetes treatment. Thus, it’s conceivable that GLP-1 may be able to revert the vicious cycle initiated by glucose toxicity, alleviating ER stress on one side, while on the other enhancing insulin signal transduction improving endothelial function. To verify this hypothesis we will take advantage of an in vitro model of glucose toxicity HUVECs incubated with GlcNAc.

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Research Fields

Medical sciences
Biological sciences

Programme Description
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
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Funding organisation / Contacts
MIUR - Programma PRIN 2010/2011

Public research
Roma - Italy