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DNA replication in eukaryotic cells: Relation between chromatin conformation and kinetics of DNA replication
Proliferation of a eukaryotic cell depends on its ability to fully replicate its genome in a finite time. DNA replication starts at chromosomal positions called replication origins. From these origins emanate two forks that propagate in opposite directions. Coordination between the activation and coalescence of replication forks is essential to ensure the finite time of cell cycle repl...
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