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The ubiquitin-proteasome system (UPS) is the major cytosolic proteolytic system, with critical functions in cell cycle control. The central role of UPS in the cell's metabolism and in oncogenes process, explains why the compounds that affect this systems, hold important interest. These molecules can be used both as biochemical tools and as novel drugs. For these reasons, proteasome inhibition has become a new promising strategy in cancer therapeutics. Several compounds, both natural and synthetic, have been found to affect UPS functionality and some proteasome inhibitors are already efficient anticancer drugs. Inspired by this scenario, we propose a project focused on assessing the ability of some molecules, with already well-know pharmacological activity, i.e. synthetic derivate of meso tetrakis(4-N-methylpyridyl)porphyrins, synthetic derivate of natural polyphenols, and quinoxalinic cavinds, to be active as proteasome inhibitors
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