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Considering the remarkable antineoplastic activity shown by 5 – membered heterocyclic analogues of the marine alkaloid nortopsentin we will synthesize indolyl-thiazolyl -6- azaindoles and indolyl-thiazolyl -5- azaindoles to verify the influence of the position of the nitrogen on the antineoplastic activity. We also intend evaluate the antineoplastic activity of the compounds synthesized.
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