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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (13/04/2013 02.37)

Spectroscopic and structural characterization of proteasome inhibitors

Please note that the job is no longer active!

The ubiquitin-proteasome system (UPS) is the major cytosolic proteolytic system, with critical functions in cell cycle control. The central role of UPS in the cell's metabolism and in oncogenes process, explains why the compounds that affect this systems, hold important interest. These molecules can be used both as biochemical tools and as novel drugs. For these reasons, proteasome inhibition has become a new promising strategy in cancer therapeutics. Several compounds, both natural and synthetic, have been found to affect UPS functionality and some proteasome inhibitors are already efficient anticancer drugs. Inspired by this scenario, we propose a project focused on assessing the ability of some molecules, with already well-know pharmacological activity, i.e. synthetic derivate of meso tetrakis(4-N-methylpyridyl)porphyrins, synthetic derivate of natural polyphenols, and quinoxalinic cavinds, to be active as proteasome inhibitors

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Research Fields

Chemistry


Programme Description
Number of awards per year1
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programmehttp://www.unict.it/content/bando-543
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfileNot defined
Employment contract with full social securityyes
Total amount per fellowship per year19367.00
Currencyeuro
Covers salaryyes
Maximum duration of fellowship12
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Application deadline

30/04/2013

Other fellowship details
Fellowship ID

51316

Funding organisation / Contacts
Università degli Studi di Catania

Public research
Catania - Italy
www.unict.it
E-mails
dsc@unict.it

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