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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (11/04/2013 02.24)

Real time monitoring of liver oxidative stress injuries by means of an innovative methodology based on integrated autofluorescence optical biopsy. Application to transplantation procedure

Please note that the job is no longer active!

Oxidative stress enhances the risk of liver transplantation failure, in particular for fatty livers, increasingly considered to overcome the shortage of donor organs. Optical Biopsy-AutoFluorescence (OB-AF) based monitoring of oxidative stress is here investigated on liver models (normal/fatty/under experimental conditions of transplantation). Considering that excitation light makes AF to rise from naturally present biomolecules reflecting their relationship with tissue functional state, the research will focus on the AF characterization as an intrinsic diagnostic parameter as to: i) NAD(P)H and flavins, endogenous fluorophores strictly involved in redox events in oxidative stress, and bilirubin, a bile biomarker; ii) validation of OB-AF to monitor stress oxidative injuries, to support and guide transplantation phases, with reference to conventional anatomopathological correlates; ii) implementation of a compact and user-friendly fiber-optic based prototype for OB-AF analysis.

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Research Fields

Medical sciences


Programme Description
Number of awards per year1
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programmewww.igm.cnr.it
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfileNot defined
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Application deadline

27/05/2013

Other fellowship details
Fellowship ID

51251

Funding organisation / Contacts
IGM-CNR

Public research
Pavia - Italy
www.igm.cnr.it
E-mails
bottiroli@igm.cnr.itPhones
0382986412

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