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Oxidative stress enhances the risk of liver transplantation failure, in particular for fatty livers, increasingly considered to overcome the shortage of donor organs. Optical Biopsy-AutoFluorescence (OB-AF) based monitoring of oxidative stress is here investigated on liver models (normal/fatty/under experimental conditions of transplantation). Considering that excitation light makes AF to rise from naturally present biomolecules reflecting their relationship with tissue functional state, the research will focus on the AF characterization as an intrinsic diagnostic parameter as to: i) NAD(P)H and flavins, endogenous fluorophores strictly involved in redox events in oxidative stress, and bilirubin, a bile biomarker; ii) validation of OB-AF to monitor stress oxidative injuries, to support and guide transplantation phases, with reference to conventional anatomopathological correlates; ii) implementation of a compact and user-friendly fiber-optic based prototype for OB-AF analysis.
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