Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (11/04/2013 02.24)

Combining Sulindac with natural compounds as an innovative approach to prevent cancer in a new Apc-driven model of colon carcinogenesis

Please note that the job is no longer active!

Side effects of non steroidal anti-inflammatory drugs (NSAID), like Sulindac (SU) hamper their use for chemoprevention in familial adenomatous polyposis (FAP) and sporadic colorectal cancer (CRC) patients, at high risk. Mutations in APC, causing FAP and present in CRC, confer resistance to apoptosis. NSAID, as well as natural compounds like curcumin (CU) or 3,3’-Diindolylmethane (DIM), endowed of chemopreventive activity, increase apoptosis with various mechanisms. Recently, PIRC rat (polyposys in rat colon) mutated in Apc, has been described as a genetic model of FAP. Aiming at finding an effective chemopreventive strategy with minimal side effects we propose a combination of low doses of SU, together with DIM and CU to prevent carcinogenesis in PIRC. This combination will be also tested in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats, a model of sporadic CRC. Mechanisms of action and characterization of PIRC rats will be also carried out

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Research Fields

Pharmacological sciences - Clinical pharmacology

Programme Description
Number of awards per year1
Annual budget29829
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
Employment contract with full social securityyes
Total amount per fellowship per year29829
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
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Funding organisation / Contacts
Dipartimento di NEUROFARBA Università degli Studi di Firenze

Public research
Firenze - Italy