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http://www.unimib.it/link/news.jsp?2468359911799532492 positron emission tomography is a nuclear medical imaging technique that produces a three-dimensional image of functional processes in the human body. To this purpose, this technique requires the use of specific drugs, called radiopharmaceuticals or radiotracers, characterized by a positron emission and, thus, able to induce an indirect emission of gamma rays. The present project requires the syntesis of 11C- and 18F-labeled radioligands, such as raclopride, PK11195 and VC701. PK11195 and raclopride are drugs already marketed for both humans and animals, whose in vivo metabolism is still not well documented, whereas VC701 might represent an useful and innovative radiotracer for the evaluation of the peripheral benzodiazepine receptor (TSPO). The project requires a skilled person, able to synthesize the described radiopharmaceuticals and to use HPLC systems for the detection of metabolites in blood and tissues.
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