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h2. Rules of engagement: differential activation of the PI3K isoforms p110α and p110δ in lymphocytes
The PI3Ks are a family of lipid kinases which are essential for mammalian development and function. Immune cells can express up to 8 different isoforms of PI3K divided into three classes. The class I PI3Ks p110α, p110β, p110δ and p110γ can each be recruited to different receptors in B cells and T cells. Our laboratory has defined distinct roles for p110α and p110δ during lymphocyte activatio...
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