Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (28/03/2013 03.35)

A mouse model to study the response of Delta16HER2-driven tumorogenesis to immunotherapies targeting HER2

Please note that the job is no longer active!

The main goals of this project are:

1)Evaluating the effectiveness of early and prolonged mu4D5 (the murine form of

trastuzumab)treatment in Δ16HER2-LUC mouse.

2)Establishing Δ16HER2-expressing cell lines from mammary tumors explanted from

Δ16HER2-LUC mice.These cell lines will represent a useful tool for studing the

oncogenic Δ16HER2 signaling pathways and the molecular events that contribute tracellular and transmembrane domains of Δ 16HER2(Δ16HuHuT) human splice variant, in comparison with HuHuT, encoding the fully

human wild-type extracellular and transmembrane domains of HER2.

4)Evaluating the response of Δ16HER2-LUC transgenic mouse to novel epitopebased

DNA vaccines, coding for chimeric proteins containing the Fc-region of mouse IgG2A and novel HER2 epitopes, identified using a phage-displayed collection human HER2 fragments.

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields

Biological sciences

Eligibility criteria

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Programme Description
Number of awards per year1
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Total amount per fellowship per year22.947
Covers salaryyes
Covers travel and subsistenceno
Maximum duration of fellowship24
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Other fellowship details


Funding organisation / Contacts

Private with public mission
Milano - Italy