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Viruses initiate infection by attaching to the target cell using cellular receptors. The molecular mechanisms following virus attachment that promote internalization of the virus/receptor complex are poorly understood. Similarly, it remains unclear how non-enveloped viruses gain access to the cytosol of infected cells as these viruses lack a lipid bilayer and as such cannot fuse with the host membrane.
Here using reovirus (rotavirus) as a model virus for non-enveloped viruses, we will determi...
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