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Most symptoms of dementia are found in schizophrenia, a chronic, devastating, and costly mental illness affecting about 1% of the world population.Besides these neurochemical and neuropathological changes, a large body of data further suggests implication of inflammatory processes.The study of epigenetic has provided a platform whereby the impact of environmental factors. In particular, DNA methylation, is a highly significative epigenetic mechanism and has been observed during inflammation. SHPs are proteins tyrosine phosphatase ubiquitously expressed in hematopoietic and non-hematopoietic cells. In particular SHP-1 is expressed through transcription from two separate promoters.We will analyze gene expression and promoter region of the SHP1 gene in PBMC of schizophrenic patients, in order to verify potential aberrant methylation of the promoter region.
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a) the titles and scientific publications including: a PhD or equivalent qualification obtained abroad, the degree of specialization of the medical area, the certificates of attendance at post-graduate courses taken abroad as well as the performance of a documented research at public and tested by means of contracts, grants or assignments, both in Italy and abroad (60 points out of 100).
b) interview (40 points out of a hundred). Can not be allowed to interview candidates who have obtained less than 20/100 in the valuation of securities. The bankruptcy proceedings will conclude with the winner and the formation of a list of suitable valid up to a maximum of one year, whose use is restricted to the specific requirements specified in the notice
the research grant under this contract shall be granted after a comparative evaluation based on the qualifications presented by applicants
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