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This study aims to further elucidate the genetic basis and pathophysiologic mechanisms of life-threatening arrhythmias in the context of Long QT Syndrome (LQTS), through the availability of a uniquely large cohort of patients with LQTS and negative at molecular screening on known genes. Exome-sequencing will be used to identify novel disease-causing mutations in already known genes with characteristics of high severity and mutations in novel genes that could be important for arrhythmogenesis. Functional characterization of the new variants will be improved through the new in vitro model of cardiomyocytes differentiated from cardiac progenitor cells. This novel and unconventional approach will allow us to test the effect of several drugs to promote the more suited and specific pharmacological approach for each patient. Additionally, we plan to optimize the molecular screening process with the creation of a LQTS gene panel to be processed with the next-generation sequencing technique.
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The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: http://www.unipv.eu/on-line/Home/Ricerca/Assegnidiricerca.html.
Main requirements are:1) university degree awarded by Italian or foreign Universities recognized as equivalent - for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment; 2) scientific or professional curriculum suitable for conducting the research activity; 3) any Ph.D. title (Art 2- par. 1).
The application form, signed in original, have to be: 1) submitted by means of the standard template that can be found at the above address; 2) supplied with the scientific-professional curriculum and proof of identity; 3) supplied with the list of publications and copies of them; 4) supplied with any further documents / certificates / self-certification foreseen by Art. 4; 5) sent by post service (no e-mail, no website) in original paper copy to the Department of interest (see Art. 4). The candidate selection will take place on the basis of the documented qualifications and a personal interview, completed by a test concerning the knowledge of one or more foreign languages (Art. 6 - par. 1)
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